Evidence map›Paper›PMID 32161987›Full record

SynthesisWorld journal of surgery2020

Guidelines for Perioperative Care for Pancreatoduodenectomy: Enhanced Recovery After Surgery (ERAS) Recommendations 2019.

Emmanuel Melloul, Kristoffer Lassen, Didier Roulin, Fabian Grass, Julie Perinel, Mustapha Adham, Erik Björn Wellge, Filipe Kunzler, Marc G Besselink, Horacio Asbun and 6 more

5 registry-linked trialsOpen access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 220 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
220citing papers in PubMed, 21 pooled it
56.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04741880 phase2 / phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Intravenous Lidocaine and Time to Regression of the Sensory Block After Spinal Anesthesia With Isobaric Bupivacaine in Patients Undergoing Surgery to Treat Skin and Soft Tissue Tumors of the Lower Limbs

TypeinterventionalSponsorInstituto Nacional de Cancer, BrazilRan2021 to 2023Enrolled66ConditionsAnesthesia, CancerArmsLidocaine IV, Saline
NCT04985071 completednot on this mapstarted 2021, after this paper: background citation

Study of Pancreatic Fistula and Bleeding Complication After Pancreaticoduodenectomy in Treatment Periampullary Cancer

Typeobservational_patient_registrySponsorVo Truong QuocRan2021 to 2023Enrolled183ConditionsPeriampullary Cancer, Pancreatic Fistula, BleedingArmsPancreaticoduodenectomy
NCT05518643 recruitingnot on this mapstarted 2022, after this paper: background citation

Enhanced Recovery Program, Patient Reported Outcomes, Surgery-specific Outcomes and Stress Response After Pancreatic Surgery: A Prospective Observational Cohort Study by the Thessalic Pancreas Study Group (ThePANas).

Typeobservational_patient_registrySponsorUniversity of ThessalyRan2022 to 2025Enrolled120ConditionsERAS, Pancreas Cancer, Pancreas, FistulaArmsERAS protocol
NCT06009224 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Effect of Enhanced Recovery After Surgery (ERAS) on Pancreaticoduodenectomy in Patients With Hepatobiliary-Pancreas (HBP) Disease

TypeinterventionalSponsorAsan Medical CenterRan2023 to 2025Enrolled334ConditionsPeriampullary Cancer, Borderline Malignancy TumorArmsERAS perioperative management
NCT07560540 narecruitingnot on this mapstarted 2025, after this paper: background citation

Implication of Nutritional Intervention in Enhanced Recovery After Surgery for Whipple Procedure/Pylorus Preserving Pancreatoduodenectomy

TypeinterventionalSponsorUniversity of Veterinary and Animal Sciences, Lahore - PakistanRan2025 to 2026Enrolled20ConditionsPancreatic Cancer, Ampulla of Vater Adenocarcinoma, Billiary Track CancerArmsNutrition Intervention
3 · Its place in the literature

Who cites it

220 citing papers in PubMed, 21 syntheses or guidelines pooled it, 484 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  4. Prophylactic abdominal drainage for pancreatic surgery.The Cochrane database of systematic reviews · 2025
    Pooled it
  5. Postoperative nutritional support after pancreaticoduodenectomy in adults.The Cochrane database of systematic reviews · 2025
    Pooled it
  6. Pooled it
  7. Guideline
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  9. The quality of guidelines on the pancreatic perioperative enhanced recovery after surgery: a systematic quality appraisal using AGREE II instrument.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  10. Enhanced recovery after surgery protocols following emergency intra-abdominal surgery: a systematic review and meta-analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Pooled it
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160 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 7 countries.

Emmanuel MelloulDepartment of Visceral Surgery, University Hospital Lausanne (CHUV), University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Kristoffer LassenDepartment of Hepatobiliary and Pancreatic Surgery, Oslo University Hospital, Oslo, Norway.
Didier RoulinDepartment of Visceral Surgery, University Hospital Lausanne (CHUV), University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Fabian GrassDepartment of Visceral Surgery, University Hospital Lausanne (CHUV), University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
Julie PerinelService de chirurgie Digestive, Hôpital Edouard Herriot, Hospices Civils De Lyon, Lyon, France.
Mustapha AdhamService de chirurgie Digestive, Hôpital Edouard Herriot, Hospices Civils De Lyon, Lyon, France.
Erik Björn WellgeDepartment of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, 20246, Hamburg, Germany.
Filipe KunzlerDivision of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL, USA.
Marc G BesselinkDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Horacio AsbunDivision of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL, USA.
Michael J ScottRoyal Surrey County Hospital NHS Foundation Trust, Guildford, UK.
Cornelis H C DejongDepartments of Surgery, Maastricht University, Maastricht, The Netherlands.
Dionisos VrochidesDivision of Hepatopancreatobiliary Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.
Thomas AloiaDepartment of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jakob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, 20246, Hamburg, Germany.
Nicolas DemartinesDepartment of Visceral Surgery, University Hospital Lausanne (CHUV), University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland. Demartines@chuv.ch.
University of Lausanne · CHHôpital Edouard Herriot · FRMiami Heart Research Institute · USUniversity Medical Center Hamburg-Eppendorf · DEAmsterdam University Medical Centers · NLCarolinas Medical Center · USMaastricht University · NLOslo University Hospital · NORoyal Surrey County Hospital · GBThe University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnhanced recovery after surgery (ERAS) pathways are now implemented worldwide with strong evidence that adhesion to such protocol reduces medical complications, costs and hospital stay. This concept has been applied for pancreatic surgery since the first published guidelines in 2012. This study presents the updated ERAS recommendations for pancreatoduodenectomy (PD) based on the best available evidence and on expert consensus.

methodsA systematic literature search was conducted in three databases (Embase, Medline Ovid and Cochrane Library Wiley) for the 27 developed ERAS items. Quality of randomized trials was assessed using the Consolidated Standards of Reporting Trials statement checklist. The level of evidence for each item was determined using the Grading of Recommendations Assessment Development and Evaluation system. The Delphi method was used to validate the final recommendations.

resultsA total of 314 articles were included in the systematic review. Consensus among experts was reached after three rounds. A well-implemented ERAS protocol with good compliance is associated with a reduction in medical complications and length of hospital stay. The highest level of evidence was available for five items: avoiding hypothermia, use of wound catheters as an alternative to epidural analgesia, antimicrobial and thromboprophylaxis protocols and preoperative nutritional interventions for patients with severe weight loss (> 15%).

conclusionsThe current updated ERAS recommendations for PD are based on the best available evidence and processed by the Delphi method. Prospective studies of high quality are encouraged to confirm the benefit of current updated recommendations.

Indexed as

Enhanced Recovery After SurgeryPancreaticoduodenectomyGuideline AdherenceHumansPerioperative Care

Identifiers

PMID32161987
OpenAlexW4211102457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.