Evidence map›Paper›PMID 32161841›Full record

ArticleJBMR plus2020

Genetic Burden Contributing to Extremely Low or High Bone Mineral Density in a Senior Male Population From the Osteoporotic Fractures in Men Study (MrOS).

Shan Chen, Mahim Jain, Shalini Jhangiani, Zeynep C Akdemir, Philippe M Campeau, Robert F Klein, Carrie Nielson, Hongzheng Dai, Donna M Muzny, Eric Boerwinkle and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Shan ChenDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Mahim JainDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Shalini JhangianiDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Zeynep C AkdemirDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Philippe M CampeauUniversity of Montreal Medical Genetics Service Montréal QC Canada.ORCID https://orcid.org/0000-0001-9713-7107
Robert F KleinSchool of Medicine Oregon Health & Science University Portland OR USA.
Carrie NielsonSchool of Medicine Oregon Health & Science University Portland OR USA.ORCID https://orcid.org/0000-0002-2619-7839
Hongzheng DaiDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.ORCID https://orcid.org/0000-0002-0103-876X
Donna M MuznyDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Eric BoerwinkleHuman Genome Sequencing Center Baylor College of Medicine Houston TX USA.
Richard A GibbsDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Eric S OrwollSchool of Medicine Oregon Health & Science University Portland OR USA.
James R LupskiDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Jennifer E PoseyDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.
Brendan LeeDepartment of Molecular and Human Genetics Baylor College of Medicine Houston TX USA.ORCID https://orcid.org/0000-0001-8573-4211
Baylor College of Medicine · USOregon Health & Science University · USKennedy Krieger Institute · USUniversité de Montréal · CA

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
UNDERSTANDING FXTAS AMONG MALES WITH THE FMR1 PREMUTATIONP30HD024064 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI ROSENMUND, CHRISTIAN · 1988 to 2013
$29.4M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Baylor-Johns Hopkins Center for Mendelian GeneticsUM1HG006542 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2016 to 2020
$14.5M
Project 3: Collagen post-translational modification and cross-linking in OIP01HD070394 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN · 2011 to 2020
$13.4M
Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
GWAS in MrOS and SOFRC2AR058973 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2009 to 2010
$5.7M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
Osteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0M
NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NHGRI NIH HHS K08 HG008986NHGRI NIH HHS UM1 HG006542NIAMS NIH HHS R01 AR051124NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR066160NIA NIH HHS R56 AG061085NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NICHD NIH HHS P01 HD070394NICHD NIH HHS P30 HD024064NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

Worldwide, one in five men aged over 50 years will experience osteoporosis or a clinical bone fracture, with a greater fracture-related mortality rate than women. However, the genetic etiology of osteoporosis in men is still poorly understood. We aimed to identify the genetic variants and candidate genes associated with extremely low or high BMD for a better understanding of the biology underlying low bone density that may point to potential therapeutic targets for increasing bone mass. Subjects from the Osteoporotic Fractures in Men Study (MrOS) cohort were evaluated by age and BMI-adjusted total hip BMD. Those with BMD values 3 SDs away from the mean were selected and the remaining individuals whose adjusted BMD ranked at the highest or lowest 100 were included. Men with the lowest adjusted BMD (

Indexed as

ANALYSIS/QUANTITATION OF BONEDISEASES AND DISORDERS OF/RELATED TO BONEDXAGENETIC RESEARCHHUMAN ASSOCIATION STUDIESOSTEOPOROSIS

Identifiers

PMID32161841
PMCPMC7059823
OpenAlexW2994682237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.