Evidence map›Paper›PMID 32161833›Full record

ArticleAPL bioengineering2020

Multi-scale cellular engineering: From molecules to organ-on-a-chip.

Ngan F Huang, Ovijit Chaudhuri, Patrick Cahan, Aijun Wang, Adam J Engler, Yingxiao Wang, Sanjay Kumar, Ali Khademhosseini, Song Li

Abstract read
In one paragraph

Article in APL bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ovijit ChaudhuriDepartment of Mechanical Engineering, Stanford University, Stanford, California 94305, USA.ORCID https://orcid.org/0000-0002-9287-3401
Patrick CahanDepartment of Biomedical Engineering, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.ORCID https://orcid.org/0000-0003-3652-2540
Adam J EnglerDepartment of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, California 92093, USA.ORCID https://orcid.org/0000-0003-1642-5380
Yingxiao WangDepartment of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, California 92093, USA.ORCID https://orcid.org/0000-0003-0265-326X
Song LiDepartment of Bioengineering, University of California, Los Angeles, California 90095, USA.ORCID https://orcid.org/0000-0002-4760-8828

Funding

Role of Spatiotemporal Epigenetic Dynamics in Regulating Endothelial Gene Expressions under FlowsR01HL121365 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIEN, SHU, WANG, YINGXIAO · 2014 to 2025
$7.5M
From intra to intercellular regulatory networks that define cell type identityR35GM124725 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Patrick Cahan · 2017 to 2026
$4.5M
Locus-specific Imaging of Dynamic Histone Methylations during ReprogrammingR01GM125379 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, WANG, YINGXIAO · 2017 to 2020
$2.4M
Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer CellsR33CA204704 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, YINGXIAO · 2017 to 2019
$1.1M
Remote-Control Mechano-Genetics and Epigenetics for Live Cell ManipulationR01GM126016 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, YINGXIAO · 2018 to 2020
$1.1M
Engineering Machinery Molecules to Visualize and Actuate ImmunotherapyR21CA209629 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, YINGXIAO · 2017 to 2018
$371k
NCI NIH HHS R21 CA209629NCI NIH HHS R33 CA204704NHLBI NIH HHS R01 HL121365NIGMS NIH HHS R01 GM125379NIGMS NIH HHS R01 GM126016NIGMS NIH HHS R35 GM124725
6 · The paper itself

Abstract

Recent technological advances in cellular and molecular engineering have provided new insights into biology and enabled the design, manufacturing, and manipulation of complex living systems. Here, we summarize the state of advances at the molecular, cellular, and multi-cellular levels using experimental and computational tools. The areas of focus include intrinsically disordered proteins, synthetic proteins, spatiotemporally dynamic extracellular matrices, organ-on-a-chip approaches, and computational modeling, which all have tremendous potential for advancing fundamental and translational science. Perspectives on the current limitations and future directions are also described, with the goal of stimulating interest to overcome these hurdles using multi-disciplinary approaches.

Identifiers

PMID32161833
PMCPMC7054123

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.