ReviewJournal of exercise rehabilitation2020
The role of neuroinflammation on pathogenesis of affective disorders.
Review in Journal of exercise rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- A Systematic Review of the Predictive and Diagnostic Uses of Neuroinflammation Biomarkers for Epileptogenesis.International journal of molecular sciences · 2024Pooled it
- Photobiomodulation improves depression symptoms: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2023Pooled it
- Photobiomodulation therapy in mood disorders: a systematic review.Lasers in medical science · 2022Pooled it
- Neurobiological Mechanisms of Vitamin D in Anxiety: Evidence from Rodent Models and Bioinformatics-Based Target Identification.Nutrients · 2026Review
- Article
- Cognitive impairment and associated factors among patients with mood disorders receiving care at public hospitals in Gedeo zone, Southern Ethiopia.Social psychiatry and psychiatric epidemiology · 2026Article
- Study on the correlation between seven emotions and traditional Chinese medicine syndromes, serum IL-6 and IFN-γ in patients with primary lung cancer.Clinics (Sao Paulo, Brazil) · 2026Article
- Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons.Purinergic signalling · 2026Review
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Gut Microbiota Differences in Down Syndrome Are Most Pronounced in Childhood and Diminish With Age.International journal of microbiology · 2026Article
- Moderating effects of individual factors on the relationship between inflammation and psychophysiological states in healthy adults.Brain, behavior, & immunity - health · 2025Article
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Blue light treatment of psychiatric disorders: relationships with systemic inflammation, lipid metabolism, and clinical symptoms.BMC psychiatry · 2025Article
- Estrogenic Effect of Probiotics on Anxiety and Depression: A Narrative Review.International journal of molecular sciences · 2025Review
- Association between dietary insulin index and risk of depression, anxiety, and sleep disturbance in a group of Iranian physically active adults.BMC psychology · 2025Article
- Associations of dietary and lifestyle inflammation scores with sleep quality and mental health in hemodialysis patients: a multicenter cross-sectional study.Nutrition & metabolism · 2025Article
- Prolonged 5-week and 12-week chronic stress differentially modulates CNS expression of pro- and anti-neuroinflammatory biomarkers, brain monoamines and affective behavior in adult zebrafish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Exposome-Wide Gene-By-Environment Interaction Study of Psychotic Experiences in the UK Biobank.Biological psychiatry global open science · 2025Article
- COVID-19 and cognitive impairment: a review of the emerging evidence.Discover mental health · 2025Review
- Oral andrographolide loaded lipid nanocarriers alleviate stress behaviors and hippocampal damage in TNF alpha induced neuroinflammatory mice.Scientific reports · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests that neuroinflammation plays an important role in etiology of psychiatric disorders. Neuronflammation involves a combination of psychological, neuroendocrine, and nervous systems resulting in changes of neurotransmitter metabolism, dysregulation of the hypothalamuspituitary-adrenal axis, pathologic microglial cell activation, impaired neuroplasticity, and structural and functional brain changes affecting cognition and emotional behavior. Inflammatory cytokines have been postulated to be the possible link and culprit in the disruption of these systems. The outcome of any type of dysregulation of the immune system in the brain might lead to occurrence of depression, anxiety. This review focuses on the possible impact of dysregulated cytokine networks which may cause pathogenesis of affective disorders such as depression and anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.