Evidence map›Paper›PMID 32161708›Full record

ArticleAfrican journal of emergency medicine : Revue africaine de la medecine d'urgence2020

Association between multivitamin supplementation and mortality among patients with Ebola virus disease: An international multisite cohort study.

Derrick Yam, Adam R Aluisio, Shiromi M Perera, Jillian L Peters, Daniel K Cho, Stephen B Kennedy, Moses Massaquoi, Foday Sahr, Michael A Smit, Lindsey Locks and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of emergency medicine : Revue africaine de la medecine d'urgence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Derrick YamCenter for Statistical Sciences, Department of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Adam R AluisioDepartment of Emergency Medicine, Brown University Alpert Medical School, Providence, RI, USA.
Shiromi M PereraInternational Medical Corps, Washington, DC, USA.
Jillian L PetersBrown University, Providence, RI, USA.
Daniel K ChoBrown University, Providence, RI, USA.
Stephen B KennedyMinistry of Health, Monrovia, Liberia.
Moses MassaquoiMinistry of Health, Monrovia, Liberia.
Foday SahrSierra Leone Ministry of Defense, Freetown, Sierra Leone.
Michael A SmitDivision of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Lindsey LocksDepartment of Health Sciences, Boston University: Sargent College, Boston, USA.
Tao LiuCenter for Statistical Sciences, Department of Biostatistics, Brown University School of Public Health, Providence, RI, USA.
Adam C LevineDepartment of Emergency Medicine, Brown University Alpert Medical School, Providence, RI, USA.
Brown University · USBoston University · USChildren's Hospital of Los Angeles · USInternational Medical Corps · USMinistry of Defence · SL

Funding

Evaluation of Management Strategies for Maximizing Supportive Care for Patients with Ebola Virus DiseaseR03AI132801 · NIAID · RHODE ISLAND HOSPITAL · PI LEVINE, ADAM CARL · 2017 to 2018
$179k
NIAID NIH HHS R03 AI132801
6 · The paper itself

Abstract

introductionMicronutrient supplementation is recommended in Ebola Virus Disease (EVD) care; however, there is limited data on its therapeutic effects.

methodsThis retrospective cohort study included patients with EVD admitted to five Ebola Treatment Units (ETU) in Sierra Leone and Liberia during September 2014 to December 2015. A uniform protocol was used to guide ETU care, however, due to supply limitations, only a subset of patients received multivitamins. Data on demographics, clinical characteristics, and laboratory testing was collected. The outcome of interest was facility-based mortality and the primary predictor was multivitamin supplementation initiated within 48 h of admission. The multivitamin formulations included: thiamine, riboflavin, niacin and vitamins A, C, and D

resultsThere were 424 patients with EVD who had sufficient treatment data for analysis, of which 261 (61.6%) had daily multivitamins initiated within 48 h of admission. The mean age of the cohort was 30.5 years and 59.4% were female. In the propensity score matched analysis, mortality was 53.5% among patients receiving multivitamins and 66.2% among patients not receiving multivitamins, resulting in a relative risk for mortality of 0.81 (p = 0.03) for patients receiving multivitamins.

conclusionEarly multivitamin supplementation was associated with lower overall mortality. Further research on the impact of micronutrient supplementation in EVD is warranted.

Indexed as

Ebola virus diseaseLiberiaMortalityMultivitaminsNutritionSierra Leone

Identifiers

PMID32161708
PMCPMC7058859
OpenAlexW2997679047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.