ReviewFrontiers in psychiatry2020
Clinical Features That Evoke the Concept of Disinhibition in Tourette Syndrome.
Review in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A neural network for tics: insights from causal brain lesions and deep brain stimulation.Brain : a journal of neurology · 2022Pooled it
- Article
- A teaching tool for tic disorders: using "disinhibition" to unify the spectrum.Frontiers in psychiatry · 2025Article
- Article
- Disinhibition Is an Essential Network Motif Coordinated by GABA Levels and GABA B Receptors.International journal of molecular sciences · 2024Review
- Neuroanatomical and functional correlates in tic disorders and Tourette's syndrome: A narrative review.Ibrain · 2024Review
- Self-injurious behavior in Tourette syndrome.Journal of neurology · 2022Article
- Inhibitory Control in Children with Tourette Syndrome Is Impaired in Everyday Life but Intact during a Stop Signal Task.Journal of clinical medicine · 2022Article
- Tourette syndrome research highlights from 2020.F1000Research · 2022Review
- Myoclonus and other jerky movement disorders.Clinical neurophysiology practice · 2022Review
- Article
- Aggression Toward Others Misdiagnosed as Primary Tics.Movement disorders clinical practice · 2021Article
- Article
- Electrophysiology Echoes Brain Dynamics in Children and Adolescents With Tourette Syndrome-A Developmental Perspective.Frontiers in neurology · 2021Review
- Inhibitory Control Deficits in Children with Tic Disorders Revealed by Object-Hit-and-Avoid Task.Neural plasticity · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacity to efficiently control motor output, by either refraining from prepotent actions or disengaging from ongoing motor behaviors, is necessary for our ability to thrive in a stimulus-rich and socially complex environment. Failure to engage in successful inhibitory motor control could lead to aberrant behaviors typified by an excess of motor performance. In tic disorders and Tourette syndrome (TS) - the most common tic disorder encountered in clinics - surplus motor output is rarely the only relevant clinical sign. A range of abnormal behaviors is often encountered which are historically viewed as "disinhibition phenomena". Here, we present the different clinical features of TS from distinct categorical domains (motor, sensory, complex behavioral) that evoke the concept of disinhibition and discuss their associations. We also present evidence for their consideration as phenomena of inhibitory dysfunction and provide an overview of studies on TS pathophysiology which support this view. We then critically dissect the concept of disinhibition in TS and illuminate other salient aspects, which should be considered in a unitary pathophysiological approach. We briefly touch upon the dangers of oversimplification and emphasize the necessity of conceptual diversity in the scientific exploration of TS, from disinhibition and beyond.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.