ArticleFrontiers in aging neuroscience2020
Age-Related Decreases in Interhemispheric Resting-State Functional Connectivity and Their Relationship With Executive Function.
Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sex differences in brain homotopic co-activations: a meta-analytic study.Brain structure & function · 2022Pooled it
- Novel evidence of age-related cortical and subcortical constraints in cross-education.GeroScience · 2026Article
- Inter-Hemispheric Coordination and Ageing in Visual Working Memory: A Distributed Framework.Brain sciences · 2026Review
- MCI-LB brain networks reorganization in relation to specific cognitive domains deficits.Scientific reports · 2026Article
- Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
- Disrupted resting-state interhemispheric functional connectivity in patients with first-episode moyamoya disease.Scientific reports · 2025Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Accelerated Epigenetic Aging and Its Role in Brain Dynamics and Cognition in Young Adulthood.Human brain mapping · 2025Article
- Influence of depression severity on interhemispheric functional integration: an analysis from the REST-meta-MDD database.Brain imaging and behavior · 2025Article
- Neural correlates of basketball proficiency: An MRI study across skill levels.Journal of exercise science and fitness · 2025Article
- Normative Data for the D-KEFS Color-Word Interference and Trail Making Tests Adapted in Greek Adult Population 20-49 Years Old.NeuroSci · 2024Article
- Towards a neurodevelopmental cognitive perspective of temporal processing.Communications biology · 2024Review
- Accelerated epigenetic age is associated with whole-brain functional connectivity and impaired cognitive performance in older adults.Scientific reports · 2024Article
- Brain network mechanism on cognitive control task in the elderly with brain aging: A functional near infrared spectroscopy study.Frontiers in human neuroscience · 2023Article
- Changes in white matter functional networks across late adulthood.Frontiers in aging neuroscience · 2023Article
- Hemispheric functional segregation facilitates target detection during sustained visuospatial attention.Human brain mapping · 2022Article
- The association between head motion during functional magnetic resonance imaging and executive functioning in older adults.Neuroimage. Reports · 2022Article
- Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults.GeroScience · 2022Article
- The functional connectivity of language network across the life span: Disentangling the effects of typical aging from Alzheimer's disease.Frontiers in aging neuroscience · 2022Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Age-related alterations of functional brain networks contribute to cognitive decline. Current theories indicate that age-related intrinsic brain functional reorganization may be a critical marker of cognitive aging. Yet, little is known about how intrinsic interhemispheric functional connectivity changes with age in adults, and how this relates to critical executive functions. To address this, we examined voxel-mirrored homotopic connectivity (VMHC), a metric that quantifies interhemispheric communication, in 93 healthy volunteers (age range: 19-85) with executive function assessment using the Delis-Kaplan Executive Function System (D-KEFS) scales. Resting functional MRI data were analyzed to assess VMHC, and then a multiple linear regression model was employed to evaluate the relationship between age and the whole-brain VMHC. We observed age-related reductions in VMHC of ventromedial prefrontal cortex (vmPFC) and hippocampus in the medial temporal lobe subsystem, dorsal anterior cingulate cortex and insula in salience network, and inferior parietal lobule in frontoparietal control network. Performance on the color-word inhibition task was associated with VMHC of vmPFC and insula, and VMHC of vmPFC mediated the relationship between age and CWIT inhibition reaction times. The percent ratio of correct design scores in design fluency test correlated positively with VMHC of the inferior parietal lobule. The current study suggests that brain interhemispheric functional alterations may be a promising new avenue for understanding age-related cognitive decline.
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