Evidence map›Paper›PMID 32161526›Full record

SynthesisFrontiers in human neuroscience2020

A Multimodal Meta-Analysis of Structural and Functional Changes in the Brain of Tinnitus.

Shirui Cheng, Guixing Xu, Jun Zhou, Yuzhu Qu, Zhengjie Li, Zhaoxuan He, Tao Yin, Peihong Ma, Ruirui Sun, Fanrong Liang

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shirui ChengThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Guixing XuThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jun ZhouThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Yuzhu QuThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhengjie LiThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhaoxuan HeThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tao YinThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Peihong MaThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ruirui SunThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Fanrong LiangThe Acupuncture and Tuina School/The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain imaging studies of tinnitus patients have revealed marked changes in brain structure and function, but there are inconsistencies in those findings. In this meta-analysis, we investigated concurrence across studies to clarify those abnormalities in brain structure and function in tinnitus. Neuroimaging studies published up to December 6, 2019 were searched in the PubMed, Web of Science, EMBASE, and Cochrane Library databases, Chinese Nation Knowledge Infrastructure, Chinese Biomedical Literature Database, the Chongqing VIP, and Wanfang Database. Study selection, quality assessment, and data extraction were performed by two independent researchers. Anisotropic effect size signed differential mapping (AES-SDM) was used to perform a multimodal analysis of available studies reporting whole-brain structural or functional data in tinnitus patients. There were 14 studies that met the inclusion criteria. The structural dataset comprised 242 tinnitus patients and 217 matched healthy subjects (HS), while the functional dataset included 130 tinnitus patients and 140 matched HS. Our analysis revealed structural alterations in the superior temporal gyrus, middle temporal gyrus (MTG), angular gyrus, caudate nucleus, superior frontal gyrus, and supplementary motor area, as well as functional differences in the MTG, middle occipital gyrus, precuneus, and right inferior parietal (excluding supramarginal and angular) gyri. The multimodal analysis revealed significant differences in the right MTG of tinnitus patients relative to HS. These findings suggest the involvement of the cortico-striatal circuits in the neuropathology of tinnitus.

Indexed as

meta-analysismultimodalneuroimagingsigned differential mappingtinnitusvoxel-based morphometry

Identifiers

PMID32161526
PMCPMC7053535
OpenAlexW3007594722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.