ReviewClinical, cosmetic and investigational dermatology2020
Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics.
Review in Clinical, cosmetic and investigational dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 181 citations in OpenAlex.
- Synthetic Dermal Fillers in Treating Acne Scars: A Comparative Systematic Review.Journal of cosmetic dermatology · 2025Pooled it
- Efficacy and Safety of Polycaprolactone in Treating Nasolabial Folds: A Prospective, Multicenter, and Randomized Controlled Trial.Facial plastic surgery : FPS · 2023Trial
- Cellularized Thermoformed Scaffolds with Human Septal Chondrocytes Support In Vivo Cartilage Maturation for Auricular Reconstruction.Journal of functional biomaterials · 2026Article
- Regenerative Functional Microspheres for Aesthetic Medicine: Mechanism, Materials, Fabrication, and Clinical Applications.Advanced healthcare materials · 2026Review
- First Insights on the Upcoming Role of Next-Generation PLLA-LASYNPRO in Aesthetic and Regenerative Medicine: A Survey of Experts-the PLLA-LASYNPRO Rationale.Facial plastic surgery : FPS · 2026Article
- Smart functionalized cartilage repair microspheres: Concepts and applications.Materials today. Bio · 2026Review
- Advances in electrospun nanofiber-based personal protective equipment for active filtration.Discover nano · 2026Review
- Periorbital Structural and Functional Modulation Following Liquid-Type Polycaprolactone Treatment: A Pilot Study.Journal of clinical medicine · 2026Article
- The Effective Biodegradation of Poly(ε-caprolactone) by Engineered YeastInternational journal of molecular sciences · 2026Article
- Bioinspired Polymeric Scaffolds for Improvement of Angiogenesis and Tissue Engineering: A Review.Polymers · 2026Review
- BIO3 Protocol: Clinical and In Vitro Evidence of Triple Biostimulation With CaHA and P (LA/CL) Threads.Journal of cosmetic dermatology · 2026Article
- A Dual-Phase Approach to Facial Rejuvenation Integrating Contouring and Ligamentous (CL Code) Anchoring With a Polycaprolactone-Based Collagen Stimulator.Journal of cosmetic dermatology · 2026Article
- A Rat Model Investigation of Enhanced Facial Rejuvenation via PCL Microsphere-Induced Superior Collagen Neogenesis in the Supraperiosteal Plane.Aesthetic plastic surgery · 2026Article
- Time-Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε-caprolactone)-Poly(N,N'-dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media.Angewandte Chemie (International ed. in English) · 2026Article
- Assessment of physicochemical alterations in 3D-printed biodegradable implants under biomimetic conditions for cranial defect repair.Biomedical microdevices · 2026Article
- Synthetic Polymer-Based Interventions in Wound Healing: A Clinical Perspective on their Efficacy and Limitations.Current pharmaceutical design · 2026Review
- A Preliminary Study of Polycaprolactone Filler After Hyaluronidase for Facial Overfilled Syndrome.Clinical, cosmetic and investigational dermatology · 2026Article
- Injectable Fillers for Atrophic Acne Scars: A Systematic Review of Mechanisms, Evidence, and Clinical Algorithms.Clinical, cosmetic and investigational dermatology · 2026Review
- Ultrasonographic Features of Polycaprolactone Granulomatous Reactions: Case Series and a Literature Review.Aesthetic surgery journal. Open forum · 2026Article
- Efficacy and Safety of Polycaprolactone Filler in Nonsurgical Rhinoplasty: A Pilot Study.Clinical, cosmetic and investigational dermatology · 2026Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. PCL is biocompatible and biodegradable. Its specific physicochemical and mechanical properties, viscoelasticity and ease of shaping led to the production of PCL-based products with various shapes and durations dependent on its biodegradation kinetics. PCL has been safely used in the biomedical field for more than 70 years, from sutures to tissue and organ replacement by 3D printing. The PCL-based collagen stimulator is composed of PCL microspheres suspended in a carboxymethyl-cellulose gel carrier providing immediate and sustained volumizing effects when injected; the morphology, the biocompatibility of the PCL microspheres embedded with the collagen fibers produced all contribute to the creation of a unique 3D scaffold for a sustained effect. Its safety has been investigated in clinical studies and vigilance surveys. Recently published experts' recommendations on injection modalities and techniques should help further optimize treatment outcome and safety. This paper also integrates reviews and recommendations on the prevention and management of adverse events related to dermal and subdermal fillers including the PCL-based collagen stimulator. In addition, in terms of efficacy and safety, this product benefits from its daily clinical use in esthetics worldwide and continuous extensive fundamental and clinical research, both on it and the PCL polymer. Forthcoming data from further investigations will reinforce knowledge of the product and procedures in the field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.