Evidence map›Paper›PMID 32161457›Full record

ArticleInternational journal of nanomedicine2020

Silver-Containing Titanium Dioxide Nanocapsules for Combating Multidrug-Resistant Bacteria.

Nelly Hérault, Julia Wagner, Sarah-Luise Abram, Jérôme Widmer, Lenke Horvath, Dimitri Vanhecke, Carole Bourquin, Katharina M Fromm

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Nelly Hérault *Department of Chemistry, University of Fribourg, Fribourg 1700, Switzerland.
Julia Wagner *Department of Medicine, University of Fribourg, Fribourg 1700, Switzerland.ORCID 0000-0002-5019-6932
Sarah-Luise AbramDepartment of Chemistry, University of Fribourg, Fribourg 1700, Switzerland.ORCID 0000-0001-8555-9898
Jérôme WidmerDepartment of Medicine, University of Fribourg, Fribourg 1700, Switzerland.
Lenke HorvathDepartment of Chemistry, University of Fribourg, Fribourg 1700, Switzerland.
Dimitri VanheckeAdolphe Merkle Institute, University of Fribourg, Fribourg 1700, Switzerland.
Carole Bourquin *Department of Medicine, University of Fribourg, Fribourg 1700, Switzerland.ORCID 0000-0003-3862-4583
Katharina M Fromm *Department of Chemistry, University of Fribourg, Fribourg 1700, Switzerland.ORCID 0000-0002-1168-0123
University of Fribourg · CHUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundJoint arthroplasty has improved the quality of life of patients worldwide, but infections of the prosthesis are frequent and cause significant morbidity. Antimicrobial coatings for implants promise to prevent these infections.

methodsWe have synthesized nanocapsules of titanium dioxide in amorphous or anatase form containing silver as antibacterial agent and tested their impact on bacterial growth. Furthermore, we explored the possible effect of the nanocapsules on the immune system. First, we studied their uptake into macrophages using a combination of electron microscopy and energy-dispersive spectroscopy. Second, we exposed immune cells to the nanocapsules and checked their activation state by flow cytometry and enzyme-linked immunosorbent assay.

resultsSilver-containing titanium dioxide nanocapsules show strong antimicrobial activity against both

conclusionOur bactericidal silver-containing titanium dioxide nanocapsules fulfill important prerequisites for biomedical use and represent a promising material for the coating of artificial implants.

Indexed as

AnimalsAnti-Bacterial AgentsCoated Materials, BiocompatibleDrug Resistance, Multiple, BacterialEscherichia coliMacrophagesMice, Inbred C57BLMicrobial Sensitivity TestsNanocapsulesSilverStaphylococcus aureusTitaniumAnti-Bacterial AgentsCoated Materials, BiocompatibleNanocapsulesSilverTitaniumtitanium dioxideantimicrobial effectimmune cell uptakemultidrug-resistant S. aureussilver nanoparticlestitanium dioxide nanocapsules

Identifiers

PMID32161457
PMCPMC7050041
OpenAlexW3008917752

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.