ArticleMucosal immunology2021
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus.
Article in Mucosal immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 43 citations in OpenAlex.
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- A wave of Thetis cells imparts tolerance to food antigens early in life.Science (New York, N.Y.) · 2025Article
- Dendritic cell expression of MyD88 is required for rotavirus-induced B cell activation.Journal of virology · 2025Article
- Radial glia integrin avb8 regulates cell autonomous microglial TGFβ1 signaling that is necessary for microglial identity.Nature communications · 2025Article
- Single-Cell RNA-Sequencing Analysis Provides Insights into IgA Nephropathy.Biomolecules · 2025Review
- Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis.Kidney international reports · 2024Article
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- Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity.Trends in immunology · 2024Review
- Mast cells help organize the Peyer's patch niche for induction of IgA responses.Science immunology · 2024Article
- APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.Nature immunology · 2023Article
- Establishment of isotype-switched, antigen-specific B cells in multiple mucosal tissues using non-mucosal immunization.NPJ vaccines · 2023Article
- The Interplay between Integrins and Immune Cells as a Regulator in Cancer Immunology.International journal of molecular sciences · 2023Review
- The thin line between conventional dendritic cells (cDCs) and group 3 innate lymphoid cells (ILC3s) in the gut.International immunology · 2023Article
- IgA Nephropathy: Current Understanding and Perspectives on Pathogenesis and Targeted Treatment.Diagnostics (Basel, Switzerland) · 2023Review
- Novel antigen-presenting cell imparts TNature · 2022Article
- A RORγtNature · 2022Article
- Rotavirus-Induced Expansion of Antigen-Specific CD8 T Cells Does Not Require SignalingFrontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.