ArticleScientific reports2020
Antigenic characterization of novel H1 influenza A viruses in swine.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Molecular, Functional, and Ecological Characterization of Antarctic Penguin Orthoavulaviruses (AVV17-19).Animals : an open access journal from MDPI · 2026Article
- Comprehensive molecular epidemiology of influenza viruses in Brazil: insights from a nationwide analysis.Virus evolution · 2025Article
- Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control.Emerging microbes & infections · 2024Article
- Review
- Replication kinetics of novel swine influenza A viruses: an approach to vaccine production.Austral journal of veterinary sciences · 2024Article
- Novel influenza A viruses in pigs with zoonotic potential, Chile.Microbiology spectrum · 2024Article
- Novel introductions of human-origin H3N2 influenza viruses in swine, Chile.Frontiers in veterinary science · 2024Article
- Article
- Testing for genetic mutation of seasonal influenza virus.Journal of applied statistics · 2023Article
- Cross-protection of commercial vaccines against Chilean swine influenza A virus using the guinea pig model as a surrogate.Frontiers in veterinary science · 2023Article
- Review of genome sequencing technologies in molecular characterization of influenza A viruses in swine.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Article
- Prediction of Omicron Virus Using Combined Extended Convolutional and Recurrent Neural Networks Technique on CT-Scan Images.Interdisciplinary perspectives on infectious diseases · 2022Article
- Zooming in on the molecular characteristics of swine influenza virus circulating in Colombia before and after the H1N1pdm09 virus.Frontiers in veterinary science · 2022Article
- Circulation patterns of human seasonal Influenza A viruses in Chile before H1N1pdm09 pandemic.Scientific reports · 2021Article
- Ubiquitous influenza A virus in Chilean swine before the H1N1pdm09 introduction.Transboundary and emerging diseases · 2021Article
- Article
- Article
- Case Report: First Report and Phylogenetic Analysis of Porcine Astroviruses in Chile.Frontiers in veterinary science · 2021Article
- Low Dose Pig Anti-Influenza Virus Monoclonal Antibodies Reduce Lung Pathology but Do Not Prevent Virus Shedding.Frontiers in immunology · 2021Article
- Antigenic and Genetic Characterization of Swine Influenza Viruses Identified in the European Region of Russia, 2014-2020.Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Novel H1N2 influenza A viruses (IAVs) in swine have been identified in Chile co-circulating with pandemic H1N1 2009-like (A(H1N1)pdm09-like) viruses. The objective of this study was to characterize antigenically the swine H1 IAVs circulating in Chile. Genetic analysis based on the HA1 domain and antigenic analysis by hemagglutination inhibition assay were carried out. Three antigenic clusters were identified, named Chilean H1 A (ChH1A), Chilean H1 B (ChH1B), and A(H1N1)pdm09-like. The antigenic sites of ChH1A and ChH1B strains were 10-60% distant from those of commercial vaccine strains at the amino acid sequence level. Antigenic variants were identified within the clusters ChH1A and A(H1N1)pdm09-like. Substitutions in the main antigenic sites (E153G in Sa, Q193H in Sb, D168N in Ca1, P137S in Ca2, and F71L in Cb) were detected in variants from the ChH1A cluster, whereas only a single substitution in antigenic site Sa (G155E) was detected in variants from A(H1N1)pdm09-like cluster, which confirms the importance to carrying out antigenic analyses in addition to genetic analyses to evaluate control measures such as vaccination. These results highlight the need to update vaccines for swine in Chile and the importance of continued surveillance to determine the onward transmission of antigenic variants in Chilean pig populations.
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Registered trials
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