ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Pattern Separation Underpins Expectation-Modulated Memory.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- Expectation violation enhances short-term source memory.Psychonomic bulletin & review · 2025Article
- Task-relevant representational spaces in human memory traces.PLoS computational biology · 2025Article
- Visual Statistical Learning Alters Low-Dimensional Cortical Architecture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- When personality meets surprise: individual differences in memory for unexpected events.Frontiers in psychology · 2025Article
- Unexpected Twists: Electrophysiological Correlates of Encoding and Retrieval of Events Eliciting Prediction Error.Psychophysiology · 2025Article
- Predictions enable top-down pattern separation in the macaque face-processing hierarchy.Nature communications · 2024Article
- Long-term, multi-event surprise correlates with enhanced autobiographical memory.Nature human behaviour · 2023Article
- Predictions transform memories: How expected versus unexpected events are integrated or separated in memory.Neuroscience and biobehavioral reviews · 2023Review
- The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Reward Uncertainty and Expected Value Enhance Generalization of Episodic Memory.International journal of environmental research and public health · 2022Article
- Experiencing Surprise: The Temporal Dynamics of Its Impact on Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Hippocampal representations switch from errors to predictions during acquisition of predictive associations.Nature communications · 2022Article
- Article
- Increasing stimulus similarity drives nonmonotonic representational change in hippocampus.eLife · 2022Article
- Mnemonic prediction errors promote detailed memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Electro-Acupuncture Improve the Early Pattern Separation in Alzheimer's Disease MiceFrontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pattern separation and completion are fundamental hippocampal computations supporting memory encoding and retrieval. However, despite extensive exploration of these processes, it remains unclear whether and how top-down processes adaptively modulate the dynamics between these computations. Here we examine the role of expectation in shifting the hippocampus to perform pattern separation. In a behavioral task, 29 participants (7 males) learned a cue-object category contingency. Then, at encoding, one-third of the cues preceding the to-be-memorized objects, violated the studied rule. At test, participants performed a recognition task with old objects (targets) and a set of parametrically manipulated (very similar to dissimilar) foils for each object. Accuracy was found to be better for foils of high similarity to targets that were contextually unexpected at encoding compared with expected ones. Critically, there were no expectation-driven differences for targets and low similarity foils. To further explore these effects, we implemented a computational model of the hippocampus, performing the same task as the human participants. We used representational similarity analysis to examine how top-down expectation interacts with bottom-up perceptual input, in each layer. All subfields showed more dissimilar representations for unexpected items, with dentate gyrus (DG) and CA3 being more sensitive to expectation violation than CA1. Again, representational differences between expected and unexpected inputs were prominent for moderate to high levels of input similarity. This effect diminished when inputs from DG and CA3 into CA1 were lesioned. Overall, these novel findings strongly suggest that pattern separation in DG/CA3 underlies the effect that violation of expectation exerts on memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.