Evidence map›Paper›PMID 32161123›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis.

Maryann P Platt, Kevin A Bolding, Charlotte R Wayne, Sarah Chaudhry, Tyler Cutforth, Kevin M Franks, Dritan Agalliu

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Choroid Plexus Abnormalities in Autoimmune Encephalitis.CNS neuroscience & therapeutics · 2026
    Article
  4. Article
  5. Article
  6. [Association Between T Lymphocyte Mitochondrial Function and Disease Activity in Anti-NMDAR Encephalitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
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  13. Article
  14. Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Maryann P PlattGraduate Program in Neurobiology and Behavior, Columbia University Irving Medical Center, New York, NY 10032.
Kevin A BoldingDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27708.
Charlotte R WayneDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032.
Sarah ChaudhryDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032.
Tyler CutforthDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032.
Kevin M FranksDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27708; franks@neuro.duke.edu da191@cumc.columbia.edu.
Dritan AgalliuDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032; franks@neuro.duke.edu da191@cumc.columbia.edu.
Columbia University Irving Medical Center · USDuke Medical Center · USDuke University Hospital · US

Funding

Odor Coding in Piriform CortexR01DC015525 · NIDCD · DUKE UNIVERSITY · PI Kevin Franks · 2016 to 2026
$4.1M
Cellular and humoral immune mechanisms underlying neurovascular dysfunction in autoimmune encephalitisR01MH112849 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, CUTFORTH, TYLER · 2017 to 2020
$2.1M
miR regulation of the neurovasculature function in health and diseaseR01NS107344 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEDERSEN, IRENE MUNK · 2018 to 2021
$1.7M
Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's diseaseR01AG078352 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dritan Agalliu, Andrew Alexander Sproul · 2025 to 2026
$837k
CRCNS: Odor processing by cortical neural circuits R01DC016782 · NIDCD · DUKE UNIVERSITY · PI FRANKS, KEVIN · 2017 to 2020
$716k
Th17 cell-mediated CNS damage in response to recurrent S. pyogenes intranasal infectionsR56MH109987 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, CUTFORTH, TYLER · 2016 to 2016
$400k
NIA NIH HHS R01 AG078352NIDCD NIH HHS R01 DC015525NIDCD NIH HHS R01 DC016782NIMH NIH HHS R01 MH112849NIMH NIH HHS R56 MH109987NINDS NIH HHS R01 NS107344
6 · The paper itself

Abstract

Antibodies against neuronal receptors and synaptic proteins are associated with a group of ill-defined central nervous system (CNS) autoimmune diseases termed autoimmune encephalitides (AE), which are characterized by abrupt onset of seizures and/or movement and psychiatric symptoms. Basal ganglia encephalitis (BGE), representing a subset of AE syndromes, is triggered in children by repeated group A

Indexed as

Disease Models, AnimalAnimalsAutoantibodiesBasal GangliaBlood-Brain BarrierBrainEncephalitisEncephalomyelitis, Autoimmune, ExperimentalFemaleHashimoto DiseaseMiceMicrogliaNeuronsOlfaction DisordersOlfactory PerceptionStreptococcal InfectionsAutoantibodiesautoimmune encephalitisblood–brain barrierolfactory circuitrypostinfectious basal ganglia encephalitisTh17 lymphocyte

Identifiers

PMID32161123
PMCPMC7104239
OpenAlexW3011479596

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.