Evidence map›Paper›PMID 32161099›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

MHC-E-Restricted CD8

Benjamin J Burwitz, Patrick K Hashiguchi, Mandana Mansouri, Christine Meyer, Roxanne M Gilbride, Sreya Biswas, Jennie L Womack, Jason S Reed, Helen L Wu, Michael K Axthelm and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. CD8Science advances · 2024
    Article
  11. Instability of the HLA-E peptidome of HIV presents a major barrier to therapeutic targeting.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Identification of HLA-E BindingJournal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Benjamin J BurwitzVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0001-7767-022X
Patrick K HashiguchiVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
Mandana MansouriVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0003-1299-0817
Christine MeyerVir Biotechnology, Portland, OR 97239.
Roxanne M GilbrideVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0001-6040-104X
Sreya BiswasVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
Jennie L WomackVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0002-4941-3696
Jason S ReedVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
Helen L WuVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0001-7101-5160
Michael K AxthelmVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.ORCID 0000-0002-1984-5906
Scott G HansenVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
Louis J PickerVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006.
Klaus FrühVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006; fruehk@ohsu.edu sacha@ohsu.edu.ORCID 0000-0001-8014-3877
Jonah B SachaVaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006; fruehk@ohsu.edu sacha@ohsu.edu.ORCID 0000-0002-7633-3122
Oregon Health & Science University · USOregon National Primate Research Center · USVIR Biotechnology (United States) · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
A nonhuman primate model of stem cell transplantation to understand determinants of post-transplant SIV clearanceR01AI129703 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SACHA, JONAH B. · 2017 to 2025
$7.8M
Understanding Unconventional CD8+ T cell Responses in Protection from HIVR01AI140888 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANSEN, SCOTT G, SACHA, JONAH B. · 2018 to 2023
$4.4M
A universal MHC-E-restricted T cell vaccine for HIVR01AI117802 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI SACHA, JONAH B. · 2015 to 2018
$3.5M
Adoptive MHC-E-Restricted T Cell Therapy for the Treatment of Chronic Hepatitis B Virus InfectionR01AI144008 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI BURWITZ, BENJAMIN J · 2019 to 2023
$3.4M
Non-canonical epitope presentation and antigen processing by MHC-ER01AI175459 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI Klaus J Fruh, Jonah B. Sacha · 2023 to 2026
$2.8M
NIAID NIH HHS R01 AI117802NIAID NIH HHS R01 AI129703NIAID NIH HHS R01 AI140888NIAID NIH HHS R01 AI144008NIAID NIH HHS R01 AI175459NIH HHS P51 OD011092
6 · The paper itself

Abstract

Currently 247 million people are living with chronic hepatitis B virus infection (CHB), and the development of novel curative treatments is urgently needed. Immunotherapy is an attractive approach to treat CHB, yet therapeutic approaches to augment the endogenous hepatitis B virus (HBV)-specific T cell response in CHB patients have demonstrated little success. In this study, we show that strain 68-1 rhesus macaque (RM) CMV vaccine vectors expressing HBV Ags engender HBV-specific CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesHepatitis B, ChronicHepatitis B virusHepatocytesHistocompatibility Antigens Class IMacaca mulattaHistocompatibility Antigens Class I

Identifiers

PMID32161099
PMCPMC8109620
OpenAlexW3011870092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.