ArticleDiabetes care2020
Performance of High-Sensitivity Cardiac Troponin Assays to Reflect Comorbidity Burden and Improve Mortality Risk Stratification in Older Adults With Diabetes.
Article in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Pooled it
- Impact of subthreshold troponin levels and temporal trends on short term adverse cardiovascular outcomes in patients discharged from the emergency department: a RACE-IT trial substudy.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Trial
- Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease.Cardiovascular diabetology · 2022Trial
- Metformin and high-sensitivity cardiac troponin I and T trajectories in type 2 diabetes patients: a post-hoc analysis of a randomized controlled trial.Cardiovascular diabetology · 2022Trial
- Clinical and Economic Implications of High-Sensitivity Troponin-Informed Admission Strategies in Non-AMI Chest Pain.Journal of cardiovascular development and disease · 2026Article
- Article
- Temporal Trends and Clinical Implications of Cardiac Troponin Testing in Emergency Departments: A Multicenter Retrospective Study.Journal of clinical medicine · 2026Article
- High-sensitivity cardiac troponin I and frailty: associations with the frailty index and Fried phenotype in older women.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Dietary patterns and obesity are associated with type 2 diabetes risk in elderly Chinese men: a machine learning approach.Frontiers in nutrition · 2025Article
- Cardiometabolic Biomarkers and Prediction of Kidney Disease Progression: The eGFR Cohort Study.Canadian journal of kidney health and disease · 2025Article
- Prognostic value of elevated postoperative high-sensitivity troponin T in diabetes mellitus patients for ischemic events within 12 months after PCI in ACS patients: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Cardiac Biomarkers are Associated with Incident Fracture Risk in Advanced Chronic Kidney Disease.Calcified tissue international · 2024Article
- Distribution and prognostic value of high-sensitivity cardiac troponin T and I across glycemic status: a population-based study.Cardiovascular diabetology · 2024Article
- Candidate biomarkers as predictors of future kidney disease and cardiovascular dysfunction in adolescents with type 2 diabetes.Diabetes research and clinical practice · 2023Article
- Associations between inflammation, coagulation, cardiac strain and injury, and subclinical vascular disease with frailty in older men: a cross-sectional study.BMC geriatrics · 2022Article
- Accounting for frailty and multimorbidity when interpreting high-sensitivity troponin I tests in oldest old.Journal of the American Geriatrics Society · 2022Article
- Elevated circulating high-sensitivity cardiac troponin t and cardiac remodeling in obesity.BMC cardiovascular disorders · 2021Article
- Associations between inflammation, cardiovascular biomarkers and incident frailty: the British Regional Heart Study.Age and ageing · 2021Article
- Elderly patients with non-cardiac admissions and elevated high-sensitivity troponin: the prognostic value of renal function.World journal of cardiology · 2021Article
- American Diabetes Association Framework for Glycemic Control in Older Adults: Implications for Risk of Hospitalization and Mortality.Diabetes care · 2021Article
Corrections and comments
- Commented on by
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveIncorporation of comorbidity burden to inform diabetes management in older adults remains challenging. High-sensitivity cardiac troponins are objective, quantifiable biomarkers that may improve risk monitoring in older adults. We assessed the associations of elevations in high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) with comorbidities and improvements in mortality risk stratification. RESEARCH DESIGN AND
methodsWe used logistic regression to examine associations of comorbidities with elevations in either troponin (≥85th percentile) among 1,835 participants in the Atherosclerosis Risk in Communities (ARIC) Study with diabetes (ages 67-89 years, 43% male, 31% black) at visit 5 (2011-2013). We used Cox models to compare associations of high cardiac troponins with mortality across comorbidity levels.
resultsElevations in either troponin (≥9.4 ng/L for hs-cTnI, ≥25 ng/L for hs-cTnT) were associated with prevalent coronary heart disease, heart failure, chronic kidney disease, pulmonary disease, hypoglycemia, hypertension, dementia, and frailty. Over a median follow-up of 6.2 years (418 deaths), both high hs-cTnI and high hs-cTnT further stratified mortality risk beyond comorbidity levels; those with a high hs-cTnI or hs-cTnT and high comorbidity were at highest mortality risk. Even among those with low comorbidity, a high hs-cTnI (hazard ratio 3.0 [95% CI 1.7, 5.4]) or hs-cTnT (hazard ratio 3.3 [95% CI 1.8, 6.2]) was associated with elevated mortality.
conclusionsMany comorbidities were reflected by both hs-cTnI and hs-cTnT; elevations in either of the troponins were associated with higher mortality risk beyond comorbidity burden. High-sensitivity cardiac troponins may identify older adults at high mortality risk and be useful in guiding clinical care of older adults with diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.