Evidence map›Paper›PMID 32161030›Full record

Observational studyNeurology2020

Seeing ophthalmologic problems in Parkinson disease: Results of a visual impairment questionnaire.

Carlijn D J M Borm, Femke Visser, Mario Werkmann, Debbie de Graaf, Diana Putz, Klaus Seppi, Werner Poewe, Annemarie M M Vlaar, Carel Hoyng, Bastiaan R Bloem and 2 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06032130 ("Characterization of Visual Problems in Patients With Parkinson's Disease and Application of an Oculomotor and/or Perceptual Therapy Program"), which is not on this map. Cited by 45 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06032130 completednot on this mapstarted 2023, after this paper: background citation

"Characterization of Visual Problems in Patients With Parkinson's Disease and Application of an Oculomotor and/or Perceptual Therapy Program"

TypeobservationalSponsorUniversity of ValenciaRan2023 to 2026Enrolled160ConditionsParkinson DiseaseArmsClinical measurements, Oculomotor or perceptual therapy
3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Contrast Sensitivity Function in Parkinson's Disease: Effects of Illumination and Disease Stage.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  6. Review
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  14. Review
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  18. Review
  19. Visual Dysfunction and Occupational Performance in Persons With Parkinson's Disease.The American journal of occupational therapy : official publication of the American Occupational Therapy Association · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlijn D J M BormFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria. carlijn.borm@radboudumc.nl.
Femke VisserFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Mario WerkmannFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Debbie de GraafFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Diana PutzFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Klaus SeppiFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Werner PoeweFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Annemarie M M VlaarFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Carel HoyngFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Bastiaan R BloemFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Thomas TheelenFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.
Nienke M de VriesFrom Parkinson Centre Nijmegen (ParC), Department of Neurology, Donders Institute for Brain, Cognition and Behaviour (C.D.J.M.B., D.d.G., B.R.B., N.M.d.V.), and Department of Ophthalmology (C.H., T.T.), Radboud University Medical Centre, Nijmegen; Department of Neurology (F.V., A.M.M.V.), Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands; and Departments of Neurology (M.W., K.S., W.P.) and Ophthalmology (D.P.), Medical University Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the prevalence and clinical effect of ophthalmologic symptoms in patients with Parkinson disease (PD), compared with controls, using a standardized questionnaire.

methodsIn this observational, cross-sectional, multicenter study, 848 patients with PD and 250 healthy controls completed the Visual Impairment in Parkinson's Disease Questionnaire (VIPD-Q). The VIPD-Q addressed 4 domains according to structures: (1) ocular surface; (2) intraocular; (3) oculomotor; and (4) optic nerve. The questionnaire also assessed the effect of ophthalmologic symptoms on daily activities.

resultsOne or more ophthalmologic symptoms were reported by 82% (95% confidence interval [CI], 80-85) of patients, compared with 48% (95% CI, 42-54) of controls (

conclusionPatients with PD have a higher prevalence of ophthalmologic symptoms than controls. Moreover, these frequently interfere with daily activities. A screening questionnaire such as the VIPD-Q may help with identifying ophthalmologic symptoms in PD, thereby enabling more timely treatment.

Indexed as

Activities of Daily LivingAdultAgedAged, 80 and overCross-Sectional StudiesEye DiseasesFemaleHumansMaleMass ScreeningMiddle AgedParkinson DiseasePrevalenceQuality of LifeSurveys and QuestionnairesVision, Low

Identifiers

PMID32161030
PMCPMC7251522

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.