Evidence map›Paper›PMID 32160776›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

GFAP (Glial Fibrillary Acidic Protein)-Positive Progenitor Cells Contribute to the Development of Vascular Smooth Muscle Cells and Endothelial Cells-Brief Report.

Islam Osman, Liang Wang, Guoqing Hu, Zeqi Zheng, Jiliang Zhou

Open access · hybridAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 21 citations in OpenAlex.

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  20. Neurovascular Coupling in Development and Disease: Focus on Astrocytes.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Islam OsmanFrom the Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University (I.O., L.W., G.H., J.Z.).
Liang WangFrom the Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University (I.O., L.W., G.H., J.Z.).
Guoqing HuFrom the Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University (I.O., L.W., G.H., J.Z.).
Zeqi ZhengDepartment of Cardiology, The First Affiliated Hospital of Nanchang University, Jiangxi, China (L.W., Z.Z.).
Jiliang ZhouFrom the Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University (I.O., L.W., G.H., J.Z.).
Augusta University · US

Funding

The novel smooth muscle-specific lncRNA CARMN is a critical regulator of smooth muscle phenotypeR01HL149995 · NHLBI · AUGUSTA UNIVERSITY · PI ZHOU, JILIANG · 2020 to 2023
$2.0M
Novel role of the lncRNA NEAT1 in smooth muscle phenotypic modulationR01HL132164 · NHLBI · AUGUSTA UNIVERSITY · PI ZHOU, JILIANG · 2016 to 2019
$1.5M
American Heart Association-American Stroke Association 18POST34030400NHLBI NIH HHS R01 HL132164NHLBI NIH HHS R01 HL149995
6 · The paper itself

Abstract

objectiveWhile GFAP (glial fibrillary acidic protein) is commonly used as a classical marker for astrocytes in the central nervous system, GFAP-expressing progenitor cells give rise to other cell types during development. The goal of this study was to investigate whether GFAP-expressing progenitor cells contribute to the development of vascular cells in major arteries. Approach and Results: To label GFAP-expressing progenitor cells and their progeny, we crossed

conclusionsOur study demonstrates that vascular smooth muscle cells and endothelial cells within the same vascular segment are developmentally heterogeneous, where varying proportions of vascular smooth muscle cells and endothelial cells are contributed by GFAP-positive progenitor cells.

Indexed as

Cell DifferentiationCell LineageAnimalsEndothelial Progenitor CellsFemaleGenes, ReporterGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsLuminescent ProteinsMaleMice, Inbred C57BLMice, TransgenicMuscle, Smooth, VascularMyocytes, Smooth MuscleNeural CrestPhenotypeenhanced green fluorescent proteinGlial Fibrillary Acidic ProteinGreen Fluorescent ProteinsLuminescent ProteinsRed Fluorescent Proteinastrocytesendothelial cellsgenes, reportermuscle, smoothneural crest

Identifiers

PMID32160776
PMCPMC7180117
OpenAlexW3011104567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.