ArticleCell reports2020
Cellular Classes in the Human Brain Revealed In Vivo by Heartbeat-Related Modulation of the Extracellular Action Potential Waveform.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Synthetic Data Generation for Classifying Electrophysiological and Morpho-Electrophysiological Neurons from Mouse Visual Cortex.Neuroinformatics · 2025Article
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- Body as First Teacher: The Role of Rhythmic Visceral Dynamics in Early Cognitive Development.Perspectives on psychological science : a journal of the Association for Psychological Science · 2025Article
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- Single neurons in the thalamus and subthalamic nucleus process cardiac and respiratory signals in humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cell class-specific electric field entrainment of neural activity.bioRxiv : the preprint server for biology · 2024Article
- Dataset of human-single neuron activity during a Sternberg working memory task.Scientific data · 2024Article
- Spatiotemporal dedifferentiation of the global brain signal topography along the adult lifespan.Human brain mapping · 2023Article
- Distinct neuronal representation of small and large numbers in the human medial temporal lobe.Nature human behaviour · 2023Article
- Interoceptive rhythms in the brain.Nature neuroscience · 2023Review
- Associations between in vitro, in vivo and in silico cell classes in mouse primary visual cortex.Nature communications · 2023Article
- Associations betweenbioRxiv : the preprint server for biology · 2023Article
- Advances in human intracranial electroencephalography research, guidelines and good practices.NeuroImage · 2022Review
- Single-neuron models linking electrophysiology, morphology, and transcriptomics across cortical cell types.Cell reports · 2022Article
- Distinct neuronal types contribute to hybrid temporal encoding strategies in primate auditory cortex.PLoS biology · 2022Article
- The temporal dedifferentiation of global brain signal fluctuations during human brain ageing.Scientific reports · 2022Article
- Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex.Nature neuroscience · 2022Article
- PredictingFrontiers in neuroinformatics · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Determining cell types is critical for understanding neural circuits but remains elusive in the living human brain. Current approaches discriminate units into putative cell classes using features of the extracellular action potential (EAP); in absence of ground truth data, this remains a problematic procedure. We find that EAPs in deep structures of the brain exhibit robust and systematic variability during the cardiac cycle. These cardiac-related features refine neural classification. We use these features to link bio-realistic models generated from in vitro human whole-cell recordings of morphologically classified neurons to in vivo recordings. We differentiate aspiny inhibitory and spiny excitatory human hippocampal neurons and, in a second stage, demonstrate that cardiac-motion features reveal two types of spiny neurons with distinct intrinsic electrophysiological properties and phase-locking characteristics to endogenous oscillations. This multi-modal approach markedly improves cell classification in humans, offers interpretable cell classes, and is applicable to other brain areas and species.
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