Evidence map›Paper›PMID 32160524›Full record

ArticleImmunity2020

Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity.

Anne-Laure Flamar, Christoph S N Klose, Jesper B Moeller, Tanel Mahlakõiv, Nicholas J Bessman, Wen Zhang, Saya Moriyama, Vladislava Stokic-Trtica, Lucille C Rankin, Gregory Garbès Putzel and 6 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 106 citations in OpenAlex.

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  17. Decoding serotonin: the molecular symphony behind depression.Frontiers in cellular neuroscience · 2025
    Review
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  19. Article
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Anne-Laure FlamarJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Christoph S N KloseJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, 12203 Berlin, Germany.
Jesper B MoellerJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA; Department of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark.
Tanel MahlakõivJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Nicholas J BessmanJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Wen ZhangJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Saya MoriyamaJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Vladislava Stokic-TrticaDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, 12203 Berlin, Germany; Max-Planck Institute for Infection Biology, Berlin, Germany.
Lucille C RankinJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Gregory Garbès PutzelJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA.
Hans-Reimer RodewaldDivision of Cellular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.
Zhengxiang HePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lili ChenPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sergio A LiraPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Gerard KarsentyDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032, USA.
David ArtisJill Roberts Institute for Research in Inflammatory Bowel Disease, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY 10021, USA. Electronic address: dartis@med.cornell.edu.
Cornell University · USIcahn School of Medicine at Mount Sinai · USColumbia University Irving Medical Center · USGerman Cancer Research Center · DEMax Planck Institute for Infection Biology · DEUniversity of Southern Denmark · DK

Funding

Transcriptomic CoreP01AG032959 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gerard Karsenty · 2010 to 2026
$39.7M
Regulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0M
Mechanisms associated with flares and remission in colitisR01DK110352 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2017 to 2025
$5.1M
Innate immunity and inflammation following helminth infectionR01AI074878 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2008 to 2019
$4.2M
Immuno-regulation of GI nematode infectionR01AI061570 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2004 to 2013
$4.1M
Molecular pathogenesis of intestinal serrated polypsR01CA161373 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LIRA, SERGIO A. · 2011 to 2020
$3.7M
Regulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7M
Neuropeptide-mediated regulation of antihelminth immunityR01AI151599 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ARTIS, DAVID, SIRACUSA, MARK CHRISTOPHER · 2020 to 2024
$3.2M
Neuro-immune regulation of intestinal inflammationR01DK126871 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2020 to 2024
$3.2M
Regulation and function of innate lymphoid cells during influenza virus infectionR01AI102942 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2013 to 2017
$2.1M
Cytokine regulation of anti-helminth immunityR01AI097333 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2012 to 2016
$2.0M
The molecular basis of host-microbiota interactionsF32AI124517 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI BESSMAN, NICHOLAS J. · 2017 to 2020
$193k
NCI NIH HHS R01 CA161373NIAID NIH HHS F32 AI124517NIAID NIH HHS R01 AI061570NIAID NIH HHS R01 AI074878NIAID NIH HHS R01 AI095466NIAID NIH HHS R01 AI097333NIAID NIH HHS R01 AI102942NIAID NIH HHS R01 AI151599NIAID NIH HHS U01 AI095608NIA NIH HHS P01 AG032959NIDDK NIH HHS R01 DK110352NIDDK NIH HHS R01 DK126871
6 · The paper itself

Abstract

Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue homeostasis. Two distinct subsets of ILC2s have been described: steady-state natural ILC2s and inflammatory ILC2s, which are elicited following helminth infection. However, how tissue-specific cues regulate these two subsets of ILC2s and their effector functions remains elusive. Here, we report that interleukin-33 (IL-33) promotes the generation of inflammatory ILC2s (ILC2

Indexed as

Immunity, CellularAnimalsCell LineageDisease SusceptibilityGene Expression RegulationImmunity, InnateImmunity, MucosalInducible T-Cell Co-Stimulator ProteinInterleukin-33LarvaLymph NodesMiceMice, Inbred C57BLMice, KnockoutNippostrongylusPrimary Cell CultureIcos protein, mouseIl33 protein, mouseInducible T-Cell Co-Stimulator ProteinInterleukin-33Tph1 protein, mouseTryptophan Hydroxylasegroup 2 innate lymphoid cellshelminth infectionIL-33ILC2sinflammatory ILC2sTph1tryptophan hydroxylase 1type 2 immunity

Identifiers

PMID32160524
PMCPMC7218677
OpenAlexW3012077793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.