Observational studyJoint diseases and related surgery2020
Tranexamic acid decreases the risk of revision for acute and delayed periprosthetic joint infection after total knee replacement.
Observational study in Joint diseases and related surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Comparison between peri-articular injection and intra-articular injection of tranexamic acid during total knee arthroplasty: A meta-analysis.Joint diseases and related surgery · 2022Pooled it
- The efficacy and safety of tranexamic acid in lumbar surgery: A meta-analysis of randomized-controlled trials.Joint diseases and related surgery · 2022Pooled it
- Consensus document on the management of wound closure in orthopaedic surgery.EFORT open reviews · 2025Review
- The emerging role of tranexamic acid and its principal target, plasminogen, in skeletal health.Acta pharmaceutica Sinica. B · 2024Review
- Fewer severe infections with tranexamic acid in patients with hematologic malignancies.Research and practice in thrombosis and haemostasis · 2024Article
- Validation of the antibacterial effect of topically applied tranexamic acid usingFrontiers in microbiology · 2024Article
- Primary total knee arthroplasty in patients with a significant bone defect in the medial tibial plateau: Case series and literature review.International journal of surgery case reports · 2023Article
- Review
- A Propensity-Matched Analysis of Tranexamic Acid and Acute Respiratory Distress Syndrome in Trauma Patients.The Journal of surgical research · 2022Article
- Risk Factors for Periprosthetic Joint Infection after Primary Total Knee Arthroplasty.Journal of clinical medicine · 2022Review
- Effect of Tranexamic Acid against Staphylococcus spp. and Cutibacterium acnes Associated with Peri-Implant Infection: Results from anMicrobiology spectrum · 2022Article
- Tranexamic Acid in Combination With Vancomycin or Gentamicin Has a Synergistic Effect Against Staphylococci.Frontiers in microbiology · 2022Article
- Use of tranexamic acid may reduce the need for routine tourniquet use in total knee arthroplasty.Joint diseases and related surgery · 2022Article
- Bone cement with screw augmentation technique for the management of moderate tibial bone defects in primary knee arthroplasty patients with high body mass index.Joint diseases and related surgery · 2021Article
- Histopathological and immunohistochemical investigation of the local and systemic effects of tranexamic acid on the healing of the Achilles tendon in rats.Joint diseases and related surgery · 2021Article
- Intravenous tranexamic acid is associated with safe reduced blood loss and transfusion rate in one-stage exchange for infected hip arthroplasty.Joint diseases and related surgery · 2021Article
- Assessment of periprosthetic joint infection prevention methods amongst Turkish orthopedic surgeons in total joint replacement: A survey.Joint diseases and related surgery · 2020Article
- Does tourniquet use decrease blood loss following primary total knee arthroplasty in Jehovah's Witness patients?Joint diseases and related surgery · 2020Article
- To sacrifice or replace the posterior cruciate ligament in primary total knee arthroplasty?Joint diseases and related surgery · 2020Article
- Are outpatient total hip and knee arthroplasties safe?Joint diseases and related surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to analyze the effect of intravenous administration of tranexamic acid (TA) on reducing the risk of revision for acute and delayed periprosthetic joint infection (PJI) after primary total knee replacement (TKR). PATIENTS AND
methodsThis prospective observational cohort study included 1,529 TKRs (396 males, 1,133 females; mean age 67.8 years; range, 44 to 85.1 years) performed between January 2003 and October 2017. We analyzed the revision rate for acute and delayed PJI in a group of 787 TKRs with preoperatively intravenously administered TA (TA group) in comparison with a group of 742 TKRs without administration of TA (non-TA group). Multiple logistic regression analysis was used to evaluate significant predictors of TKR revision for acute and delayed PJI.
resultsRevision surgery due to PJI was recorded in one patient in the TA group and eight patients in the non-TA group. Cumulative revision rate of TKR was significantly lower in the TA group (0.13% vs. 1.08%, hazard ratio 0.113; 95% confidence interval [CI] 0.0147-0.937; p=0.043). Multivariate logistic regression analysis confirmed two predictors of revision: being aged over 75 years at the time of primary surgery (odds ratio [OR] 8.464; 95% CI: 2.016-35.54; p=0.004) and male gender (OR: 7.9; 95% CI: 1.879-33.26; p=0.005). The use of TA was shown as the significant protective factor (OR: 0.109; 95% CI: 0.0128-0.929; p=0.043).
conclusionWe have found a lower cumulative revision rate of TKR for acute and delayed PJI when TA was used. We think that the preoperative intravenous use of TA may be an effective, safe and inexpensive method for the prevention of PJI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.