Evidence map›Paper›PMID 32160298›Full record

Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020

Differential effects of phosphate binders on vitamin D metabolism in chronic kidney disease.

Charles Ginsberg, Leila R Zelnick, Geoffrey A Block, Glenn M Chertow, Michel Chonchol, Andrew Hoofnagle, Bryan Kestenbaum, Ian H de Boer

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. The Vitamin D Metabolite Ratio Is Associated With Changes in Bone Density and Fracture Risk in Older Adults.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Charles GinsbergDivision of Nephrology-Hypertension, University of California, San Diego, San Diego, CA, USA.
Leila R ZelnickDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, USA.
Geoffrey A BlockNephrology, Reata Pharmaceuticals, Inc., Plano, TX, USA.
Glenn M ChertowDivision of Nephrology, Stanford University School of Medicine, Palo Alto, CA, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Anschutz Medical Center, Aurora, CO, USA.
Andrew HoofnagleDepartment of Laboratory Medicine, University of Washington, Seattle, WA, USA.
Bryan KestenbaumDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, USA.
Ian H de BoerDivision of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA, USA.
University of Washington · USReata Pharmaceuticals (United States) · USStanford University · USUniversity of Colorado Anschutz Medical Campus · USVA San Diego Healthcare System · US

Funding

Influence of Vitamin D Binding Protein on Clinical Measures of Vitamin D Status and Bone HealthK23DK118197 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, CHARLES · 2018 to 2022
$1.0M
NIDDK NIH HHS K23 DK118197
6 · The paper itself

Abstract

backgroundPhosphate binders are commonly used in the treatment of patients with hyperphosphatemia. While phosphate binders are used to lower phosphate, the effects of specific phosphate binder types on vitamin D metabolism are unknown.

methodsWe performed a secondary analysis of the Phosphate Normalization Trial in which patients with moderate to advanced chronic kidney disease were randomized to receive either placebo, sevelamer carbonate, lanthanum carbonate or calcium acetate for 9 months. We evaluated changes in serum concentrations of vitamin D metabolites including 24,25-dihydroxyvitamin D3 [24,25(OH)2D3], 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the ratio of 24,25(OH)2D3 to 25-hydroxyvitamin D [the vitamin D metabolite ratio (VMR)] and the ratio of serum 1,25(OH)2D to 25-hydroxyvitamin D.

resultsCompared with placebo, randomization to the calcium acetate arm was associated with a 0.6 ng/mL (95% CI 0.2, 1) and 13.5 pg/ng (95% CI 5.5, 21.5) increase in 24,25(OH)2D and VMR, respectively, and a 5.2 pg/mL (95% CI 1.1, 9.4) reduction in 1,25(OH)2D. Randomization to sevelamer carbonate was associated with a 0.5 ng/mL (95% CI -0.9, -0.1) and 11.8 pg/ng (95% CI -20, -3.5) reduction in 24,25(OH)2D3 and VMR, respectively. There was no association of the sevelamer arm with the change in 1,25(OH)2D3, and randomization to lanthanum carbonate was not associated with a change in any of the vitamin D metabolites.

conclusionAdministration of different phosphate binders to patients with moderate to severe CKD results in unique changes in vitamin D metabolism.

Indexed as

AcetatesAgedCalcium CompoundsChelating AgentsDouble-Blind MethodFemaleHumansHyperphosphatemiaLanthanumMaleMiddle AgedPhosphatesPrognosisRenal Insufficiency, ChronicSevelamerVitamin DAcetatescalcium acetateCalcium CompoundsChelating AgentsLanthanumlanthanum carbonatePhosphatesSevelamerVitamin Dchronic renal insufficiencyCKD-MBDmineral metabolismphosphate bindersvitamin D

Identifiers

PMID32160298
PMCPMC7139206
OpenAlexW3012098185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.