ArticlePloS one2020
Impact of blood glucose abnormalities on outcomes and disease severity in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Predictive value of optic nerve sheath diameters on cerebral performance category scale in patients with impaired consciousness in the emergency department: a prospective pilot study.International journal of emergency medicine · 2026Article
- Association Between Hemoglobin Glycation Index and Delirium Risk in Sepsis Patients in the Intensive Care UnitBalkan medical journal · 2026Article
- Associations of serum glucose/potassium ratio with short-term and long-term mortality in sepsis patients: a retrospective cohort study based on the MIMIC-IV database.Scientific reports · 2025Article
- Hypoglycemia and glycemic variability in acute myocardial infarction: the lesser-known aspects of glycemic control.Cardiovascular diabetology · 2025Review
- Association of blood urea nitrogen to glucose ratio with 365-day mortality in critically ill patients with chronic kidney disease: a retrospective study.Scientific reports · 2025Article
- Comparison of multiple machine learning methods for predicting postoperative hyperglycemia in patients without diabetes undergoing cardiac surgery.Frontiers in cardiovascular medicine · 2025Article
- The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs.Physiological reports · 2025Article
- Noniatrogenic hypoglycemia: A universal marker for poor outcomes.JTCVS open · 2024Article
- Article
- Triglyceride-glucose index and clinical outcomes in sepsis: A retrospective cohort study of MIMIC-IV.Journal of cellular and molecular medicine · 2024Article
- Combined sepsis- and renal dysfunction-induced hypoglycaemia in an older patient taking cibenzoline.Clinical case reports · 2024Article
- Prognostic Value of Serum Glucose Level in Critically Ill Septic Patients on Admission to Pediatric Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2023Article
- Intensive insulin therapy in sepsis patients: Better data enables better intervention.Heliyon · 2023Review
- Post-Transplant and In-Hospital Risk Factors for ARDS After Hematopoietic Stem Cell Transplantation.Respiratory care · 2023Article
- Expert consensus on the glycemic management of critically ill patients.Journal of intensive medicine · 2022Article
- Impact of diabetes mellitus on outcomes of patients with sepsis: an updated systematic review and meta-analysis.Diabetology & metabolic syndrome · 2022Review
- High Albumin Level Is Associated With Regression of Glucose Metabolism Disorders Upon Resolution of Acute Liver Inflammation in Hepatitis B-Related Cirrhosis.Frontiers in cellular and infection microbiology · 2022Article
- Clotting Dysfunction in Sepsis: A Role for ROS and Potential for Therapeutic Intervention.Antioxidants (Basel, Switzerland) · 2021Review
- Type 2 diabetes mellitus and sepsis: state of the art, certainties and missing evidence.Acta diabetologica · 2021Review
- Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia.Journal of diabetes science and technology · 2021Article
Corrections and comments
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Authors and funding
30 authors at 20 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDysglycemia is frequently observed in patients with sepsis. However, the relationship between dysglycemia and outcome is inconsistent. We evaluate the clinical characteristics, glycemic abnormalities, and the relationship between the initial glucose level and mortality in patients with sepsis.
methodsThis is a retrospective sub-analysis of a multicenter, prospective cohort study. Adult patients with severe sepsis (Sepsis-2) were divided into groups based on blood glucose categories (<70 (hypoglycemia), 70-139, 140-179, and ≥180 mg/dL), according to the admission values. In-hospital mortality and the relationship between pre-existing diabetes and septic shock were evaluated.
resultsOf 1158 patients, 69, 543, 233, and 313 patients were categorized as glucose levels <70, 70-139, 140-179, ≥180 mg/dL, respectively. Both the Acute Physiological and Chronic Health Evaluation II and Sequential Organ Failure Assessment (SOFA) scores on the day of enrollment were higher in the hypoglycemic patients than in those with 70-179 mg/dL. The hepatic SOFA scores were also higher in hypoglycemic patients. In-hospital mortality rates were higher in hypoglycemic patients than in those with 70-139 mg/dL (26/68, 38.2% vs 43/221, 19.5%). A significant relationship between mortality and hypoglycemia was demonstrated only in patients without known diabetes. Mortality in patients with both hypoglycemia and septic shock was 2.5-times higher than that in patients without hypoglycemia and septic shock.
conclusionsHypoglycemia may be related to increased severity and high mortality in patients with severe sepsis. These relationships were evident only in patients without known diabetes. Patients with both hypoglycemia and septic shock had an associated increased mortality rate.
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