ArticlePLoS genetics2020
Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity.
Article in PLoS genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Sleep regulation inFrontiers in neuroscience · 2026Review
- The use ofFrontiers in cell and developmental biology · 2026Review
- Systematic analysis of nutrient-microbiome interactions and their effects on host phenotypes inmBio · 2025Article
- Energy Deficit Is a Key Driver of Sleep Homeostasis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Targeted single cell expression profiling identifies integrators of sleep and metabolic state.G3 (Bethesda, Md.) · 2025Article
- Article
- Supplementation of essential amino acids suppresses age-associated sleep loss and sleep fragmentation but not loss of rhythm strength under yeast-restricted malnutrition in Drosophila.Journal of biochemistry · 2025Article
- Postprandial Sleep in Short-Sleeping Mexican Cavefish.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2024Article
- Mating reconciles fitness and fecundity by switching diet preference in flies.Nature communications · 2024Article
- Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024Article
- Postprandial sleep in short-sleeping Mexican cavefish.bioRxiv : the preprint server for biology · 2024Article
- Dietary restriction fails to extend lifespan of Drosophila model of Werner syndrome.G3 (Bethesda, Md.) · 2024Article
- Con-DAM: Simultaneous measurement of food intake and sleep inmicroPublication biology · 2024Article
- Neurofibromin 1 mediates sleep depth in Drosophila.PLoS genetics · 2023Article
- Modulation and neural correlates of postmating sleep plasticity in Drosophila females.Current biology : CB · 2023Article
- Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.Current biology : CB · 2023Article
- Article
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers.Current biology : CB · 2023Article
- New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress.Foods (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sleep is a nearly universal behavior that is regulated by diverse environmental stimuli and physiological states. A defining feature of sleep is a homeostatic rebound following deprivation, where animals compensate for lost sleep by increasing sleep duration and/or sleep depth. The fruit fly, Drosophila melanogaster, exhibits robust recovery sleep following deprivation and represents a powerful model to study neural circuits regulating sleep homeostasis. Numerous neuronal populations have been identified in modulating sleep homeostasis as well as depth, raising the possibility that the duration and quality of recovery sleep is dependent on the environmental or physiological processes that induce sleep deprivation. Here, we find that unlike most pharmacological and environmental manipulations commonly used to restrict sleep, starvation potently induces sleep loss without a subsequent rebound in sleep duration or depth. Both starvation and a sucrose-only diet result in increased sleep depth, suggesting that dietary protein is essential for normal sleep depth and homeostasis. Finally, we find that Drosophila insulin like peptide 2 (Dilp2) is acutely required for starvation-induced changes in sleep depth without regulating the duration of sleep. Flies lacking Dilp2 exhibit a compensatory sleep rebound following starvation-induced sleep deprivation, suggesting Dilp2 promotes resiliency to sleep loss. Together, these findings reveal innate resilience to starvation-induced sleep loss and identify distinct mechanisms that underlie starvation-induced changes in sleep duration and depth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.