Evidence map›Paper›PMID 32160149›Full record

ArticleEmerging infectious diseases2020

Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with Coronavirus Disease, United States.

Jennifer Harcourt, Azaibi Tamin, Xiaoyan Lu, Shifaq Kamili, Senthil K Sakthivel, Janna Murray, Krista Queen, Ying Tao, Clinton R Paden, Jing Zhang and 24 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 386 papers.

0numbers the graph read from it
0cells of the map it votes in
386citing papers in PubMed
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

386 citing papers in PubMed, 625 citations in OpenAlex.

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  11. Methods to Characterize Mutant Spectra of RNA Viruses: The Case of SARS-CoV-2.Methods in molecular biology (Clifton, N.J.) · 2026
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326 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 5 institutions in 1 country.

Jennifer Harcourt
Azaibi Tamin
Xiaoyan Lu
Shifaq Kamili
Senthil K Sakthivel
Janna Murray
Krista Queen
Ying Tao
Clinton R Paden
Jing Zhang
Yan Li
Anna Uehara
Haibin Wang
Cynthia Goldsmith
Hannah A Bullock
Lijuan Wang
Brett Whitaker
Brian Lynch
Rashi Gautam
Craig Schindewolf
Kumari G Lokugamage
Dionna Scharton
Jessica A Plante
Divya Mirchandani
Steven G Widen
Krishna Narayanan
Shinji Makino
Thomas G Ksiazek
Kenneth S Plante
Scott C Weaver
Stephen Lindstrom
Suxiang Tong
Vineet D Menachery
Natalie J Thornburg
Centers for Disease Control and Prevention · USOak Ridge Associated Universities · USThe University of Texas Medical Branch at Galveston · USOak Ridge Institute for Science and EducationSynergy America (United States) · US

Funding

Unlocking Zika Virus Immune Control and Pathogenesis with the Collaborative CrossU19AI100625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, HEISE, MARK T · 2012 to 2021
$36.6M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
New Paradigm for Host and Viral Gene Regulation by MERS Coronavirus nsp1R01AI114657 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MAKINO, SHINJI · 2015 to 2019
$2.1M
Analysis of Coronavirus-Host Cell InteractionsR01AI099107 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MAKINO, SHINJI · 2012 to 2016
$2.0M
Interplay between coronaviruses and nonsense-mediated mRNA decay pathwayR01AI146081 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MAKINO, SHINJI · 2020 to 2023
$1.2M
Systems Based Analysis of Host Factors that Contribute to Aging PathogenesisR00AG049092 · NIA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENACHERY, VINEET D · 2017 to 2019
$736k
NIAID NIH HHS R01 AI099107NIAID NIH HHS R01 AI114657NIAID NIH HHS R01 AI146081NIAID NIH HHS R24 AI120942NIAID NIH HHS U19 AI100625NIA NIH HHS R00 AG049092NIH HHS AI114657NIH HHS AI99107
6 · The paper itself

Abstract

The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 in January 2020. A patient in the United States was given a diagnosis of infection with this virus by the state of Washington and the US Centers for Disease Control and Prevention on January 20, 2020. We isolated virus from nasopharyngeal and oropharyngeal specimens from this patient and characterized the viral sequence, replication properties, and cell culture tropism. We found that the virus replicates to high titer in Vero-CCL81 cells and Vero E6 cells in the absence of trypsin. We also deposited the virus into 2 virus repositories, making it broadly available to the public health and research communities. We hope that open access to this reagent will expedite development of medical countermeasures.

Indexed as

AnimalsBetacoronavirusCell LineChlorocebus aethiopsCoronavirus InfectionsCOVID-19Genome, ViralHumansNasopharynxOropharynxPandemicsPneumonia, ViralSARS-CoV-2Vero CellsViral TropismVirus Replication2019 novel coronavirus diseasecharacterizationcoronavirusCOVID-19isolationPCRrespiratory infectionsSARS-CoV-2severe acute respiratory syndrome coronavirus 2United Statesviruseszoonoses

Identifiers

PMID32160149
PMCPMC7258473
OpenAlexW3009584253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.