Evidence map›Paper›PMID 32160100›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor.

Thitinan Treesaranuwattana, Kelly Yin Han Wong, Danielle L Brooks, Chee Sin Tay, Gordon H Williams, Jonathan S Williams, Luminita H Pojoga

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Lysine-specific demethylase 1 as a corepressor of mineralocorticoid receptor.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thitinan TreesaranuwattanaFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Kelly Yin Han WongFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Danielle L BrooksFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Chee Sin TayFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Gordon H WilliamsFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Jonathan S WilliamsFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Luminita H PojogaFrom the Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (T.T., K.Y.H.W., D.L.B., C.S.T., G.H.W., J.S.W., L.H.P.).
Harvard University · USBrigham and Women's Hospital · US

Funding

SCOR MOLECULAR GENETICS OF HYPERTENSIONP50HL055000 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SEELY, ELLEN W · 1996 to 2005
$13.5M
TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Epigenetic regulation of aldosterone and salt sensitivity in hypertensionR01HL127146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WILLIAMS, JONATHAN S. · 2016 to 2020
$3.3M
Caveolin-1 and vascular dysfunctionR01HL104032 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI POJOGA, LUMINITA · 2010 to 2014
$2.1M
NHLBI NIH HHS P50 HL055000NHLBI NIH HHS R01 HL104032NHLBI NIH HHS R01 HL127146NHLBI NIH HHS T32 HL007609
6 · The paper itself

Abstract

LSD1 (lysine-specific demethylase-1) is an epigenetic regulator of gene transcription. LSD1 risk allele in humans and LSD1 deficiency (

Indexed as

AldosteroneAllelesAnimalsBlood PressureEpigenesis, GeneticEplerenoneHistone DemethylasesKidneyMaleMiceMice, KnockoutMineralocorticoid Receptor AntagonistsMutationPotassiumReceptors, MineralocorticoidSignal TransductionAldosteroneEplerenoneHistone DemethylasesKDM1A protein, humanMineralocorticoid Receptor AntagonistsPotassiumReceptors, Mineralocorticoidaldosteronehypertensionlysine-specific demethylase 1mineralocorticoid receptorphenotype

Identifiers

PMID32160100
PMCPMC8160386
OpenAlexW3011421405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.