Evidence map›Paper›PMID 32159852›Full record

ArticleFEBS letters2020

Maintenance of liver glycogen during long-term fasting preserves energy state in mice.

Iliana López-Soldado, Angelo Bertini, Anna Adrover, Jordi Duran, Joan J Guinovart

Open access · bronzeAbstract read
In one paragraph

Article in FEBS letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Iliana López-SoldadoInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.ORCID 0000-0001-5890-6073
Angelo BertiniInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.
Anna AdroverInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.
Jordi DuranInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.
Joan J GuinovartInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Spain.
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESInstitute for Research in Biomedicine · ES

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
NINDS NIH HHS P01 NS097197
6 · The paper itself

Abstract

Glycogen shortage during fasting coincides with dramatic changes in hepatic adenine nucleotide levels. The aim of this work was to study the relevance of liver glycogen in the regulation of the hepatic energy state during food deprivation. To this end, we examined the response of mice with sustained increased liver glycogen content to prolonged fasting. In order to increase hepatic glycogen content, we generated mice that overexpress protein targeting to glycogen (PTG) in the liver (PTG

Indexed as

Energy MetabolismAdipose TissueAnimalsBody WeightFastingFood DeprivationGluconeogenesisGlycogenInsulinInsulin ResistanceKetonesLipid MetabolismLiverMiceMuscle, SkeletalOrgan SizeGlycogenInsulinKetonesAMPKenergy statefastinggluconeogenesisglycogenliver

Identifiers

PMID32159852
PMCPMC7282949
OpenAlexW3011831707

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.