ArticleeLife2020
Movement-related coupling of human subthalamic nucleus spikes to cortical gamma.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Dynamic neural states underpin motor symptom severity in Parkinson's disease: a longitudinal analysis of chronic cortico-subthalamic nucleus recordings.EBioMedicine · 2026Article
- Spatial propagation of movement-related basal ganglia activity predicts parkinsonian motor state.Brain : a journal of neurology · 2026Article
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- Gamma entrainment induced by deep brain stimulation as a biomarker for motor improvement with neuromodulation.Nature communications · 2025Article
- Human cortical high-gamma power scales with movement rate in healthy participants and stroke survivors.The Journal of physiology · 2025Article
- Case report: Improvement of gait with adaptive deep brain stimulation in a patient with Parkinson's disease.Frontiers in bioengineering and biotechnology · 2024Article
- A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Article
- Machine learning based brain signal decoding for intelligent adaptive deep brain stimulation.Experimental neurology · 2022Review
- The role of gamma oscillations in central nervous system diseases: Mechanism and treatment.Frontiers in cellular neuroscience · 2022Review
- Multi-scale neural decoding and analysis.Journal of neural engineering · 2021Review
- The Control of Movements via Motor Gamma Oscillations.Frontiers in human neuroscience · 2021Review
- TMS-EEG Biomarkers of Amnestic Mild Cognitive Impairment Due to Alzheimer's Disease: A Proof-of-Concept Six Years Prospective Study.Frontiers in aging neuroscience · 2021Article
- Mechanisms of Network Interactions for Flexible Cortico-Basal Ganglia-Mediated Action Control.eNeuroArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cortico-basal ganglia interactions continuously shape the way we move. Ideas about how this circuit works are based largely on models those consider only firing rate as the mechanism of information transfer. A distinct feature of neural activity accompanying movement, however, is increased motor cortical and basal ganglia gamma synchrony. To investigate the relationship between neuronal firing in the basal ganglia and cortical gamma activity during movement, we analysed human ECoG and subthalamic nucleus (STN) unit activity during hand gripping. We found that fast reaction times were preceded by enhanced STN spike-to-cortical gamma phase coupling, indicating a role in motor preparation. Importantly, increased gamma phase coupling occurred independent of changes in mean STN firing rates, and the relative timing of STN spikes was offset by half a gamma cycle for ipsilateral vs. contralateral movements, indicating that relative spike timing is as relevant as firing rate for understanding cortico-basal ganglia information transfer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.