SynthesisClinical cardiology2020
Opposite effect of ablation on early/late-phase thromboembolic incidence in patients with atrial fibrillation: A meta-analysis on more than 100 000 individuals.
Synthesis in Clinical cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4 citations in OpenAlex.
- Efficacy and Safety of Catheter Ablation Combined with Left Atrial Appendage Closure in the Treatment of Atrial Fibrillation: A Systematic Review and Meta-Analysis.Anatolian journal of cardiology · 2022Pooled it
- Opposite effect of ablation on early/late-phase thromboembolic incidence in patients with atrial fibrillation: A meta-analysis on more than 100 000 individuals.Clinical cardiology · 2020Pooled it
- Residual Stroke Risk in Atrial Fibrillation.Arrhythmia & electrophysiology review · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtrial fibrillation (AF) is an important risk factor for thromboembolic events, for which catheter ablation represents an effective therapy for rhythm control. Intuitively, ablation may reduce the incidence of thromboembolism, but data is quite limited. HYPOTHESIS: Catheter ablation was associated with the fewer risk of thromboembolism compared with nonablation in patients with AF.
methodsA systematic search was performed in PubMed, EMBASE, the Web of Science, and the Cochrane Library from inception to September 2019. Random-effects model was used to estimate the risk ratios (RR) for the thromboembolic events between the ablation and nonablation groups.
resultsTwenty-five studies (12 randomized controlled trials and 13 observational studies) with 104 687 participants were included. Pooled analysis suggested that ablation was associated with a 35% lower risk of total thromboembolic events compared to nonablation group (RR = 0.65; 95% CI, 0.51-0.82; P = .0003). When separated into early-phase (<30 days) and late-phase (>30 days) events, ablation was associated with an increased early-phase thromboembolism (RR = 1.96; 95% CI, 1.35-2.83; P = .0004) but a decreased late-phase thromboembolism (RR = 0.75; 95% CI, 0.63-0.90; P = .002). Subgroup analysis according to different study types found similar results were found in observation studies, but not in RCT studies because the sample size was too small to be conclusive.
conclusionsIn patients with AF, catheter ablation was associated with a fewer risk of overall and late-phase thromboembolism in comparison with nonablation. However, over the early postoperative period, catheter ablation was associated with the double higher risk of thromboembolic events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.