Evidence map›Paper›PMID 32159154›Full record

ArticleMaterials today. Bio2019

Shape-defined solid micro-objects from poly(d,l-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering.

A M Leferink, M P Tibbe, E G B M Bossink, L E de Heus, H van Vossen, A van den Berg, L Moroni, R K Truckenmüller

Abstract read
In one paragraph

Article in Materials today. Bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Engineering Heterogeneous Tumor Models for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  6. Cell Response in Free-Packed Granular Systems.ACS applied materials & interfaces · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A M LeferinkApplied Stem Cell Technologies Group, TechMed Centre, University of Twente, 7500 AE, Enschede, the Netherlands.
M P TibbeBIOS/Lab on a Chip Group, TechMed Centre and MESA+ Institute for Nanotechnology, University of Twente, 7500 AE, Enschede, the Netherlands.
E G B M BossinkBIOS/Lab on a Chip Group, TechMed Centre and MESA+ Institute for Nanotechnology, University of Twente, 7500 AE, Enschede, the Netherlands.
L E de HeusApplied Stem Cell Technologies Group, TechMed Centre, University of Twente, 7500 AE, Enschede, the Netherlands.
H van VossenMESA+ NanoLab, MESA+ Institute for Nanotechnology, University of Twente, 7500 AE, Enschede, the Netherlands.
A van den BergBIOS/Lab on a Chip Group, TechMed Centre and MESA+ Institute for Nanotechnology, University of Twente, 7500 AE, Enschede, the Netherlands.
L MoroniDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER, Maastricht, the Netherlands.
R K TruckenmüllerDepartment of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229 ER, Maastricht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In bottom-up tissue engineering, small modular units of cells and biomaterials are assembled toward ​larger and more complex ones. In conjunction with a new implementation of this approach, a novel method to fabricate microscale objects from biopolymers by thermal imprinting on water-soluble sacrificial layers is presented. By this means, geometrically well-defined objects could be obtained without involving toxic agents in the form of photoinitiators. The micro-objects were used as cell-adhesive substrates and cell spacers in engineered tissues created by cell-guided assembly of the objects. Such constructs can be applied both for

Indexed as

Bone tissue engineeringHot embossing/thermal imprintingHuman bone marrow stromal cellsHuman umbilical vein endothelial cellsPoly(lactic acid)Self-assembly

Identifiers

PMID32159154
PMCPMC7061620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.