ReviewMaterials today. Bio2019
Adaptive antibacterial biomaterial surfaces and their applications.
Review in Materials today. Bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 183 citations in OpenAlex.
- Programmable 4D printing of sustainable multifunctional photoresins with tissue-matched mechanics for interfacial tissue regeneration.Bioactive materials · 2027Article
- Metallothionein-Inspired Dual-Stage Ion-Regulatory Coatings With Infection-Triggered Bactericidal Activity and Long-Term Antifouling Protection.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Surface modifications of titanium dental implants: optimizing antibacterial activity and osteoimmunomodulation.Frontiers in bioengineering and biotechnology · 2026Review
- Biofilm Formation on Indwelling Medical Devices: A Review of Health and Economic Implications.International journal of microbiology · 2026Review
- Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment.Bone research · 2025Review
- Development, characterization and biological studies of Mn-doped ZnO/Ti biomaterials for regenerative medicine.Scientific reports · 2025Article
- Innovative Smart Materials in Restorative Dentistry.Journal of functional biomaterials · 2025Review
- Plasma activated PVDF-BaTiOScientific reports · 2025Article
- Multifunctional nano-delivery system based on DNase I and photodynamic therapy for combatting enterococcus faecalis biofilm infections.Scientific reports · 2025Article
- Biomaterial-Based Scaffolds as Carriers of Topical Antimicrobials for Bone Infection Prophylaxis.Polish journal of microbiology · 2025Review
- Diagnostic and therapeutic strategies in combating implanted medical device-associated bacterial biofilm infections.Folia microbiologica · 2025Review
- Preliminary survey of biofilm forming, antibiotic resistant Escherichia coli in fishes from land based aquaculture systems and open water bodies in Bangladesh.Scientific reports · 2025Article
- Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Acylase-Based Coatings on Sandblasted Polydimethylsiloxane-Based Materials for Antimicrobial Applications.Polymers · 2025Article
- Anisotropic patterns of nanospikes induces anti-biofouling and mechano-bactericidal effects of titanium nanosurfaces with electrical cue.Materials today. Bio · 2024Article
- Advances in Regenerative and Reconstructive Medicine in the Prevention and Treatment of Bone Infections.Biology · 2024Review
- Emerging strategies for the prevention of bacterial biofilm in prosthetic surgery.Translational andrology and urology · 2024Review
- Synergistic use of anti-inflammatory ketorolac and gentamicin to target staphylococcal biofilms.Journal of translational medicine · 2024Article
- Fucoidan- and Ciprofloxacin-Doped Plasma-Activated Polymer Coatings on Biodegradable Zinc: Hemocompatibility and Drug Release.ACS omega · 2023Article
- Expanding the Scope of an Amphoteric Condensed Tannin, Tanfloc, for Antibacterial Coatings.Journal of functional biomaterials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial infections on the implant surface may eventually lead to biofilm formation and thus threaten the use of implants in body. Despite efficient host immune system, the implant surface can be rapidly occupied by bacteria, resulting in infection persistence, implant failure, and even death of the patients. It is difficult to cope with these problems because bacteria exhibit complex adhesion mechanisms to the implants that vary according to bacterial strains. Different biomaterial coatings have been produced to release antibiotics to kill bacteria. However, antibiotic resistance occurs very frequently. Stimuli-responsive biomaterials have gained much attention in recent years but are not effective enough in killing the pathogens because of the complex mechanisms in bacteria. This review is focused on the development of highly efficient and specifically targeted biomaterials that release the antimicrobial agents or respond to bacteria on demands in body. The mechanisms of bacterial adhesion, biofilm formation, and antibiotic resistance are discussed, and the released substances accounting for implant infection are described. Strategies that have been used in past for the eradication of bacterial infections are also discussed. Different types of stimuli can be triggered only upon the existence of bacteria, leading to the release of antibacterial molecules that in turn kill the bacteria. In particular, the toxin-triggered, pH-responsive, and dual stimulus-responsive adaptive antibacterial biomaterials are introduced. Finally, the state of the art in fabrication of dual responsive antibacterial biomaterials and tissue integration in medical implants is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.