ArticleBMC rheumatology2020
The incidence of depression and anxiety in patients with ankylosing spondylitis: a systematic review and meta-analysis.
Article in BMC rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Experiences and perceptions of patients with ankylosing spondylitis: A systematic review and meta-synthesis of qualitative studies.PloS one · 2024Pooled it
- Prevalence of sleep disturbance in patients with ankylosing spondylitis: a systematic review and meta-analysis.Advances in rheumatology (London, England) · 2023Pooled it
- Profile of Circulatory Cytokines and Chemokines in Human Coronaviruses: A Systematic Review and Meta-Analysis.Frontiers in immunologyPooled it
- Altered hippocampal subfield functional connectivity and its association with back pain in axial spondyloarthritis: a multimodal neuroimaging study.Brain imaging and behavior · 2026Article
- Effects of neuroinflammation and neurotrophic factors on mental health of people with axial spondyloarthritis.Brain, behavior, & immunity - health · 2026Article
- Association of inflammation and serum adipocytokines with depression and anxiety burden in axial spondyloarthritis.Scientific reports · 2026Article
- Frailty in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: Current evidence and knowledge gaps.Therapeutic advances in musculoskeletal disease · 2026Review
- Risk of anxiety disorder following ankylosing spondylitis, 2012-2023: a nationwide cohort study in South Korea.Frontiers in psychiatry · 2026Article
- Gender differences in psychological features and determinates of quality of life in axial spondyloarthritis and psoriatic arthritis: a cross-sectional study.BMC psychology · 2025Article
- Association Between Diagnostic Delay and Economic and Clinical Burden in Axial Spondyloarthritis: A Multicentre Retrospective Observational Study.Rheumatology and therapy · 2025Article
- Health-related quality of life profiles of adults with arthritis and/or fibromyalgia: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Translation, cross-cultural adaptation and psychometric evaluation of the Serbian Ankylosing Spondylitis Quality of Life (ASQoL) Questionnaire (refers to r-axSpA) and its relations with disease activity and functional status indices.Journal of patient-reported outcomes · 2025Article
- Effects of depression on patients suffering from ankylosing spondylitis: a comparative study.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- Pain- and depression-related regional homogeneity changes in ankylosing spondylitis: a functional magnetic resonance imaging study.Frontiers in neurology · 2025Article
- International Map of Axial Spondyloarthritis (IMAS): results from the perspective of 5557 patients from 27 countries around the globe.RMD open · 2024Article
- Exercise Therapy Research in Ankylosing Spondylitis-Induced Back Pain: A Bibliometric Study (2004-2023).Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Exploring the emotional impact of axial Spondyloarthritis: a systematic review and thematic synthesis of qualitative studies and a review of social media.BMC rheumatology · 2023Article
- Depressive symptoms are associated with fatigue, poorer functional status and less engagement in sports in axSpA and PsA: an analysis from the RABBIT-SpA cohort.Arthritis research & therapy · 2023Article
- Impact of Loneliness and Social Isolation on Mental Health Outcomes Among Individuals With Rheumatic Diseases During the COVID-19 Pandemic.ACR open rheumatology · 2023Article
- Ankylosing spondylitis and psychiatric disorders in European population: a Mendelian randomization study.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs awareness for the importance of mental health continues to expand in rheumatology, it is important to understand the epidemiology of psychiatric complications in ankylosing spondylitis (AS) with the ultimate goal of future prevention and improved quality of care. This study aims to review evidence on the incidence and determinants of depression and/or anxiety among patients with AS.
methodsWe searched Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL Complete, and PsycINFO for full-length observational studies that involved a sample or population of patients with AS and assessed depression and/or anxiety. Primary outcomes extracted were: 1) risk estimates for depression and/or anxiety (e.g., relative risk [RR]); and 2) determinants or factors identified as independent predictors of depression and/or anxiety using multivariable regression approaches and corresponding estimates (e.g., odds ratios [OR]). Where relevant, we pooled estimates using random effects models.
resultsOut of 783 titles from our search strategy, we reviewed 39 manuscripts. Four studies assessed the incidence of depression and meta-analyzing reported estimates from three of these studies yielded a pooled RR of 1.51 (95% CI 1.28 to 1.79). Differences in risk of depression among men and women with AS were inconclusive, suggesting need for further study. The incidence of anxiety was comparatively less studied with only one included study reporting a hazard ratio of 1.85 (95% CI 1.37 to 2.49). Education level was a key determinant, with lower levels associated with higher odds of depression (OR 6.65; 9% CI 1.36 to 32.51) and anxiety (OR 9.31; 9% CI 1.39 to 62.19) among AS patients.
conclusionsOur systematic review and meta-analysis shows an increased risk of depression and anxiety among patients with AS. These findings suggest the importance of monitoring and care for psychiatric conditions in AS.
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