ArticleJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2020
Locally Aggressive Giant Cell Tumor of Bone With Pulmonary Distant Metastasis and Extrapulmonary Seeding in Pregnancy.
Article in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Recurrence of Giant Cell Tumor of Bone and Related Risk Factors: A Retrospective Analysis of 340 Cases From a Single Center.Journal of surgical oncology · 2026Article
- Multidisciplinary marvel: surgical management of aggressive giant cell tumor around the knee in pregnancy: a case report.Journal of surgical case reports · 2025Article
- Article
- Measurable progression of giant cell tumour of bone associated with pregnancy - A tertiary sarcoma centre analysis.Journal of clinical orthopaedics and trauma · 2024Article
- Giant Cell Tumor of Talus - A Case Report.Journal of orthopaedic case reports · 2022Article
- Aggressive giant cell tumour (GCT) of the distal humerus in a young pregnant woman.BMJ case reports · 2022Article
- Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giant cell tumor of bone (GCTB) is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic tumor. In this article, we present a case of a 26-year-old woman who presented with swelling at the left lower ribs during pregnancy. Surgical excision was done, and histopathology showed tumor with features consistent with GCTB. MRI preformed after delivery revealed recurrence of the mass with extensive growth reaching 17 cm with two subcutaneous satellite nodules in the adjacent abdominal wall. positron emission tomography-computed tomography (PET-CT) scan revealed bilateral fluorodeoxyglucose (FDG)-avid lung nodules. Surgical resection was done, and histopathology showed no evidence of malignant transformation. Few months later, the tumor recurred again, with peritoneal deposits. The patient underwent wide massive resection of the recurrent mass and then started on denosumab therapy. Molecular analysis of the tumor detected H3F3A G34W mutation with no copy number alterations. We are presenting this case of GCTB with pulmonary distant metastasis and extrapulmonary seeding to upsurge awareness among clinicians about the possible extreme aggressive biological behavior of GCTB that can mimic the presentation of malignant bone tumor and also to discuss the possible predictive factors of such aggressive behavior.
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