ArticleJPRAS open2020
Use of hyaluronic acid filler for enhancement of nipple projection following breast reconstruction: An easy and effective technique.
Article in JPRAS open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07008339 (Impact of Nipple Reconstruction in Mastectomized Patients Using Cross-Linked Hyaluronic Acid Injection.), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Nipple Reconstruction in Mastectomized Patients Using Cross-Linked Hyaluronic Acid Injection.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Autologous fat grafting and injectable fillers for post-reconstructive breast remodelling: A systematic review and quantitative synthesis.JPRAS open · 2026Review
- Prosthetic nipple areola complex reconstruction after breast reduction: a case report.Case reports in plastic surgery & hand surgery · 2026Article
- 3D printing of Ceffe-infused scaffolds for tailored nipple-like cartilage development.BMC biotechnology · 2024Article
- Tissue engineering strategies for breast reconstruction: a literature review of current advances and future directions.Annals of translational medicine · 2024Review
- Preserving the Nipple Projection in Breast Reduction with the Free Nipple-Areolar Graft Technique: Purse-String Suture.Aesthetic plastic surgery · 2023Article
- A case of acute motor sensory axonal neuropathy variant of Guillain Barre syndrome and anaphylaxis reaction as a complication from hyaluronic acid breast enhancement from an unlicensed beautician.Journal of surgical case reports · 2023Article
- Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model.Scientific reports · 2021Article
- Complications after breast augmentation with hyaluronic acid: a case report.Gland surgery · 2020Article
- Nipple-Areola Complex Reconstruction.Medicina (Kaunas, Lithuania) · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBreast reconstruction improves the psychological well-being of patients with breast cancer. Patients who complete nipple-areolar reconstruction are even more satisfied with their final reconstructive result. Nipple flattening is a common complication. We hypothesized that injectable soft-tissue filler can be used to augment nipple projection in patients who underwent breast reconstruction.
methodsThis is a retrospective study of patients who underwent breast reconstruction and desired an enhanced postoperative nipple projection. The patients underwent a single session of injection with a hyaluronic acid filler as an outpatient. The filler was injected intradermally at the base of the nipple until the desired nipple projection was obtained.
resultsTwelve patients and 22 breasts were included in this study. Enhanced nipple projection was observed in all cases, with an average increase of 3.0 mm in nipple height (range 2.5-4.5 mm). All injected nipples remained soft to the touch. All results were stable at a median of 7.5 months follow-up. No complications were observed.
conclusionsThe use of injectable fillers for enhanced nipple projection is a useful adjunct treatment in patients undergoing breast reconstruction. Advantages include the ability to obtain nipple projection in patients who opt to forgo nipple-areola reconstruction with local flaps, to augment reconstructed nipples in patients with thin mastectomy skin flaps especially following implant-based reconstruction, and to improve projection of the native nipple following nipple-sparing mastectomy. Another benefit of this adjunct treatment is that the injection is reversible. Filler injection is a safe and simple solution to the problem of insufficient nipple projection.
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Registered trials
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