ArticleJournal of dentistry (Shiraz, Iran)2020
In Vitro and In Vivo Evaluation of Poly (3-hydroxybutyrate)/Carbon Nanotubes Electrospun Scaffolds for Periodontal Ligament Tissue Engineering.
Article in Journal of dentistry (Shiraz, Iran), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Carbon-based nanomaterials in biomedicine and technology.Frontiers in chemistry · 2026Review
- Exploring the mechanical and biological interplay in the periodontal ligament.International journal of oral science · 2025Review
- Engineered Carbon Nanotube Scaffolds for Next-Generation Tissue Engineering: Synergizing Mechanical, Electrical, and Bioactive Properties - a Review.International journal of nanomedicine · 2025Review
- Reinforcing Restorative Dentistry: The Dual Role of Carbon Nanotubes in Material Enhancement and Therapy.International journal of dentistry · 2025Review
- Applications and interventions of polymers and nanomaterials in alveolar bone regeneration and tooth dentistry.RSC advances · 2024Review
- Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction.Bioactive materials · 2023Article
- Biocompatibility and Antimicrobial Activity of Electrospun Fibrous Materials Based on PHB and Modified with Hemin.Nanomaterials (Basel, Switzerland) · 2023Article
- Nanomaterials in Scaffolds for Periodontal Tissue Engineering: Frontiers and Prospects.Bioengineering (Basel, Switzerland) · 2022Review
- Review
- Review of Hybrid Materials Based on Polyhydroxyalkanoates for Tissue Engineering Applications.Polymers · 2021Review
- Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin.Polymers · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
statement of the problemTissue engineering was an idea, today it has become a potential therapy for several tissues in dentistry, such as periodontal disease and oral mucosa. PURPOSE: In this experimental study, periodontal regeneration is one of the earliest clinical disciplines that has achieved therapeutic application in tissue engineering. The aim of the present study was to prepare electrospun Poly (3-hydroxybutyrate) (PHB)/1% Carbon nanotubes (CNTs) scaffolds for periodontal regeneration. MATERIALS AND
method1% w/v of CNTs was added to the polymer solutions and electrospinned. Physical properties of the scaffolds were evaluated by scanning electron microscopy (SEM) and universal testing machine. Chemical characterization of the scaffolds was also assessed by Fourier-transform infrared spectroscopy (FTIR). Biological properties of the scaffolds were also evaluated in vitro by culturing periodontal ligament stem cells (PDLSCs) on the scaffolds for 10 days and in vivo by Implanting the scaffolds in rat model for 5 weeks.
resultsResults showed that the scaffolds mimicked fibrous connective tissue of the (PDL). CNTs improved the mechanical properties, similar to 23-55 years old human PDL. In vitro biocompatibility study showed more attachment and proliferation of the PDLSCs for PHB/1%CNTs scaffolds compared to the PHB controls. In vivo study showed that CNTs in the scaffolds caused mild foreign body type giant cell reaction, moderate vascularization, and mild inflammation.
conclusionThe results showed that the PHB/1%CNTs composite scaffolds might be potentially useful in periodontal regeneration.
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Registered trials
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