ArticleOpen forum infectious diseases2020
A Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention.
Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Tumor-Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Longterm efficacy of a patient focused intervention in patients with asplenia- a three year follow-up of the PrePPS trial.Infection · 2025Article
- Article
- Asplenia and spleen hypofunction.Nature reviews. Disease primers · 2022Review
- The Impact of Standardized Infectious Diseases Consultation on Postsplenectomy Care and Outcomes.Open forum infectious diseases · 2022Article
- Portal vein thrombosis following elective laparoscopic splenectomy: incidence and analysis of risk factors.Surgical endoscopy · 2022Article
- Exploring the metabolic phenotypes associated with different host inflammation of acute respiratory distress syndrome (ARDS) from lung metabolomics in mice.Rapid communications in mass spectrometry : RCM · 2021Article
- Preventing infections in children and adults with asplenia.Hematology. American Society of Hematology. Education Program · 2020Article
- miR-331 inhibits CLDN2 expression and may alleviate the vascular endothelial injury induced by sepsis.Experimental and therapeutic medicine · 2020Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluated the impact of a dedicated outpatient service on vaccination uptake after splenectomy and on the incidence of postsplenectomy sepsis.
methodsFrom 2009 to 2016 at the University Hospital Freiburg (Germany), asplenic patients were referred to a dedicated outpatient service, provided with comprehensive preventive care including vaccinations, and enrolled in a prospective cohort study. The impact of the service on vaccination uptake and the occurrence of severe sepsis/septic shock was compared between patients who had splenectomy (or were asplenic) within 3 months of study entry ("early study entry") and those who had splenectomy (or were asplenic) >3 months before study entry ("delayed study entry").
resultsA total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (
conclusionsWith dedicated outpatient care, high uptake of pneumococcal vaccination postsplenectomy was achieved. Sepsis episodes were largely of nonpneumococcal etiology in patients who had received dedicated postsplenectomy care.
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Registered trials
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