ArticleFrontiers in physiology2020
An Analytical Model for Estimating Alveolar Wall Elastic Moduli From Lung Tissue Uniaxial Stress-Strain Curves.
Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 32 citations in OpenAlex.
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- Multiscale stiffness of human emphysematous precision cut lung slices.Science advances · 2023Article
- Acinar micromechanics in health and lung injury: what we have learned from quantitative morphology.Frontiers in physiology · 2023Review
- Mechanics of lung cancer: A finite element model shows strain amplification during early tumorigenesis.PLoS computational biology · 2022Article
- 3D tissue-engineered lung models to study immune responses following viral infections of the small airways.Stem cell research & therapy · 2022Review
- Remodeling of the Aged and Emphysematous Lungs: Roles of Microenvironmental Cues.Comprehensive Physiology · 2022Article
- Computational lung modelling in respiratory medicine.Journal of the Royal Society, Interface · 2022Review
- Non-destructive vacuum-assisted measurement of lung elastic modulus.Acta biomaterialia · 2021Article
- A BioinspiredFrontiers in bioengineering and biotechnology · 2021Article
- Tenascin-C: Friend or Foe in Lung Aging?Frontiers in physiology · 2021Article
- Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review.Bio-design and manufacturing · 2021Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to be an emergent phenomenon arising from the ensemble behavior of its microscopic constituents. Such behavior includes the alignment and elongation of randomly oriented alveolar walls with initially flaccid fibers in the direction of strain. To account for the link between microscopic wall behavior and the macroscopic stress-strain curve, we developed an analytical model that represents both alignment and elongation of alveolar walls during uniaxial stretching. The model includes the kinetics and mechanical behavior of randomly oriented elastic alveolar walls that have a bending stiffness at their intersections. The alignment and stretch of the walls following incremental stretch of the tissue were determined based on energy minimization, and the total stress was obtained by differentiating the total energy density with respect to strain. The stress-strain curves predicted by the model were comparable to curves generated by a previously published numerical alveolar network model. The model was also fit to experimentally measured stress-strain curves in parenchymal strips obtained from mice with decreased lung collagen content, and from young and aged mice. This yielded estimates for the elastic modulus of an alveolar wall, which increased with age from 4.4 to 5.9 kPa (
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