Evidence map›Paper›PMID 32158386›Full record

ArticleFrontiers in aging neuroscience2020

Memory Function and Brain Functional Connectivity Adaptations Following Multiple-Modality Exercise and Mind-Motor Training in Older Adults at Risk of Dementia: An Exploratory Sub-Study.

Narlon C Boa Sorte Silva, Lindsay S Nagamatsu, Dawn P Gill, Adrian M Owen, Robert J Petrella

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02136368 (A Combined Exercise Program Plus Cognitive Training for Older Adults With Self-reported Cognitive Complaints), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02136368 nacompletednot on this map

A Combined Exercise Program Plus Cognitive Training for Older Adults With Self-reported Cognitive Complaints: The Multi-modal, Mind-motor (M4) Study

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2014 to 2016Enrolled127ConditionsCognitive Ability, GeneralArmsMulti-modal exercise, Mind-Motor Exercise, Balance and range of motion exercises
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Clinical Effectiveness of Multimodal Exercise Combined With Supportive Music and Imagery in the Management of Poststroke Mood Disorders.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Narlon C Boa Sorte SilvaSchool of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada.
Lindsay S NagamatsuSchool of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada.
Dawn P GillCentre for Studies in Family Medicine, Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Adrian M OwenThe Brain and Mind Institute, Department of Physiology and Pharmacology, and Psychology, Western University, London, ON, Canada.
Robert J PetrellaSchool of Kinesiology, Faculty of Health Sciences, Western University, London, ON, Canada.
Western University · CACentre for Family Medicine · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple-modality exercise improves brain function. However, whether task-based brain functional connectivity (FC) following exercise suggests adaptations in preferential brain regions is unclear. The objective of this study was to explore memory function and task-related FC changes following multiple-modality exercise and mind-motor training in older adults with subjective cognitive complaints.

methodsWe performed secondary analysis of memory function data in older adults [

resultsOur findings indicated that the M4 group showed greater improvements in the Paired Associates tasks compared to the M2 group at 24 weeks [mean difference: 0.47, 95% confidence interval (CI): 0.08 to 0.86,

conclusionOur findings suggest that multiple modality exercise with mind-motor training resulted in greater improvements in memory compared to an active control group. There were divergent FC adaptations including significant decreased co-activation in the precentral/postcentral gyri during the Spatial Span task. Borderline significant changes during the Paired Associates tasks in FC provided insight into the potential of our intervention to promote improvements in visuospatial memory and impart FC adaptations in brain regions relevant to Alzheimer's disease risk. CLINICAL

trial registrationThe trial was registered in ClinicalTrials.gov in April 2014, Identifier: NCT02136368.

Indexed as

cognitive trainingexercisefunctional connectivityfunctional magnetic resonance imagingmemorymind–motormultiple-modalityolder adults

Identifiers

PMID32158386
PMCPMC7052336
OpenAlexW3007323729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.