Evidence map›Paper›PMID 32158237›Full record

ArticleInfection and drug resistance2020

Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant

Hm Adnan Hameed, Yaoju Tan, Md Mahmudul Islam, Zhili Lu, Chiranjibi Chhotaray, Shuai Wang, Zhiyong Liu, Cuiting Fang, Shouyong Tan, Wing Wai Yew and 3 more

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.4field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Enhancing diagnostic efficiency of pyrazinamide resistance inCurrent research in microbial sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Pyrazinamide-resistant Tuberculosis Obscured From Common Targeted Molecular Diagnostics.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Detection of Mutations inCurrent issues in molecular biology · 2022
    Article
  13. Structural and Mechanistic Insights intoACS infectious diseases · 2022
    Article
  14. Article
  15. Article
  16. ACS chemical biology · 2021
    Article
  17. Article
  18. Characterization ofFrontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Hm Adnan Hameed *State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.
Yaoju Tan *State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Md Mahmudul IslamState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.
Zhili LuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.
Chiranjibi ChhotarayState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.
Shuai WangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.ORCID 0000-0003-0893-2534
Zhiyong LiuState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.
Cuiting FangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.ORCID 0000-0002-8045-3098
Shouyong TanState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.ORCID 0000-0002-3965-2722
Wing Wai YewStanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Nanshan ZhongNational Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China.
Jianxiong LiuState Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou, People's Republic of China.
Tianyu ZhangState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou, People's Republic of China.ORCID 0000-0001-5647-6014
Chinese Academy of Sciences · CNState Key Laboratory of Respiratory Disease · CNChinese University of Hong Kong · HKFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePyrazinamide (PZA) is a cornerstone of modern tuberculosis regimens. This study aimed to investigate the performance of genotypic testing of

methodsDrug susceptibility testing, sequencing analysis of PZA-related genes including the entire operon of

resultsOur data showed that among 448

conclusionOur study revealed that PZA

Indexed as

drug resistanceframeshift deletionmolecular diagnosisnovel mutationspyrazinamidasetuberculosis

Identifiers

PMID32158237
PMCPMC6986415
OpenAlexW3000998482

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.