ArticleNeuropsychiatric disease and treatment2020
Aberrant Thalamic-Centered Functional Connectivity in Patients with Persistent Somatoform Pain Disorder.
Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Aberrant Nodal Topological Properties and Functional Connectivity of Amygdala Subregions Underlie Emotion-Visceral Integration Impairment in IBS With Depressive Symptoms.Neural plasticity · 2026Article
- Modulation effect of acupuncture treatment on chronic neck and shoulder pain in female patients: Evidence from periaqueductal gray-based functional connectivity.CNS neuroscience & therapeutics · 2022Article
- Pain-Related Abnormal Neuronal Synchronization of the Nucleus Accumbens in Parkinson's Disease.Brain sciences · 2022Article
- Enhanced Connectivity of Thalamo-Cortical Networks in First-Episode, Treatment-Naive Somatization Disorder.Frontiers in psychiatry · 2020Article
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7 authors.
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Abstract
purposeRecent task-based fMRI studies have shown that Persistent Somatoform Pain Disorder (PSPD) patients demonstrated aberrant activity in a wide range of brain regions associated with sensation, cognition and emotion. However, these specific task-based studies could not clearly uncover the alterations in the spontaneous brain networks that were associated with the general pain-related symptoms in PSPD. PATIENTS AND
methodsIn the present study, 13 PSPD patients and 23 matched healthy controls (HCs) were enrolled. Resting state and 3D structural imaging data were collected during magnetic resonance imaging (MRI) scans. Ninety regions of interest (ROIs) were selected from the automated anatomical labeling (AAL) template. The functional connectivity toolbox "CONN" was used to calculate the functional connectivity (FC) coefficients.
resultsOur results showed that PSPD patients exhibited increased FCs between the left thalamus and the right amygdala, the right hippocampus, and multiple sub-regions of the occipital lobe when compared to HCs. Correlation analysis revealed a negative correlation between the left thalamus-right amygdala FC and the level of anxiety in PSPD patients.
conclusionThese findings suggest that the altered FC between thalamus and amygdala may be the neural mechanisms underlying the pain-related anxiety in PSPD.
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