ArticleVeterinary world2020
Cell-mediated and humoral immune profile to hydatidosis among naturally infected farm animals.
Article in Veterinary world, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Iliopsoas hydatid cyst mimicking an ovarian tumor: a diagnostic pitfall in an endemic setting-a case report.BMC infectious diseases · 2026Article
- A Novel Designed Sandwich ELISA for the Detection ofTropical medicine and infectious disease · 2023Article
- Evaluation of the Local Immune Response to Hydatid Cysts in Sheep Liver.Veterinary sciences · 2023Article
- The innate immune stimulant Amplimune® is safe to administer to young feedlot cattle.Australian veterinary journal · 2022Article
- Autoimmunity in Human CE: Correlative with The Fertility Status of The CE Cyst.Helminthologia · 2022Article
- Cytokine RT-qPCR and ddPCR for immunological investigations of the endangered Australian sea lion (PeerJ · 2020Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimCystic echinococcosis (CE) is a widespread parasitic disease caused by MATERIALS AND
methodsThirty-nine sheep, 74 cattle, and 79 camels' sera were collected and considered as CE naturally infected and ten samples from each species were graded as non-infected. Lung specimens were collected for histopathological examination. The quantitative concentrations of tumor necrosis factor-α, interleukin (IL)-6, IL-4, and IL-10 were determined. Different antigens were prepared from hydatid cyst; hydatid cyst fluid of lung origin hydatid cyst fluid of liver origin, hydatid cyst protoscoleces of lung origin (HCP-g), hydatid cyst protoscoleces of liver origin, hydatid cyst germinal layer of lung origin, and hydatid cyst germinal layer of liver origin; and characterized by gel electrophoresis and Western blotting analysis. The total specific IgG level against
resultsThe results indicated that the cellular immune response in the infected tissues was characterized by inflammatory cell penetration. The pro-inflammatory Th1 cytokine profile was predominant in infected animals in comparison with non-infected ones. However, the humoral immune response was seen as a high level of IgG in infected animals. The presented data approved that the HCP-g antigen could be considered as a delegate antigen for all other prepared antigens with an immunoreactive band at molecular weights 32 kDa.
conclusionThis study provides a fundamental insight into the events that manipulate cellular and humoral immune profiles in an intermediate host; sheep, cattle, and camel that naturally infected with CE. Hence, it was concluded that CE is a constant disease and confirm the reactivity Th1 in combating hydatid cyst. Besides, it could lead to the activation of the humoral immune response in the form of a high level of IgG.
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