ArticleThe American journal of tropical medicine and hygiene2020
Cryptorchidism in Children with Zika-Related Microcephaly.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Time to Evaluate the Clinical Repercussions of Zika Virus Vertical Transmission? A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Characterization of 843 children with Zika-related microcephaly in the first three years of life: An individual participant data meta-analysis of 12 cohorts in the Zika Brazilian Cohorts consortium.PLOS global public health · 2025Article
- Clinical spectrum of congenital Zika virus infection in Brazil: Update and issues for research development.Revista da Sociedade Brasileira de Medicina Tropical · 2024Review
- Trends in emerging vector-borne viral infections and their outcome in children over two decades.Pediatric research · 2024Review
- Virus as Teratogenic Agents.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Neighbourhood-level income and Zika virus infection during pregnancy in Recife, Pernambuco, Brazil: an ecological perspective, 2015-2017.BMJ global health · 2021Article
- The legacy of ZikaPLAN: a transnational research consortium addressing Zika.Global health action · 2021Review
- Viral infections that alter estrogen levels during pregnancy may contribute to the etiology of cryptorchidism.Basic and clinical andrology · 2021Article
- The Microcephaly Epidemic Research Group Paediatric Cohort (MERG-PC): A Cohort Profile.Viruses · 2021Article
- Zika-related adverse outcomes in a cohort of pregnant women with rash in Pernambuco, Brazil.PLoS neglected tropical diseases · 2021Article
- Sociodemographic and clinical factors associated with cryptorchidism in live births in Brazil: A 20-year analysis.Journal of public health research · 2021Article
- Article
- Surgical findings in cryptorchidism in children with Zika-related microcephaly: a case series.BMC urology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The genitourinary tract was recently identified as a potential site of complications related to the congenital Zika syndrome (CZS). We provide the first report of a series of cryptorchidism cases in 3-year-old children with Zika-related microcephaly who underwent consultations between October 2018 and April 2019 as part of the follow-up of the children cohort of the Microcephaly Epidemic Research Group, Pernambuco, Brazil. Of the 22 males examined, eight (36.4%) presented with cryptorchidism. Among 14 undescended testis cases, 11 (78.6%) could be palpated in the inguinal region. Seven of the eight children had severe microcephaly. Conventional risk factors for cryptorchidism were relatively infrequent in these children. We hypothesize that cryptorchidism is an additional manifestation of CZS present in children with severe microcephaly. As in our cases, for most of the children, the testes were located in the inguinal region, and the possible mechanisms for cryptorchidism were gubernaculum disturbance or cremasteric abnormality.
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Registered trials
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