ArticleESC heart failure2020
Acute correction of electromechanical dyssynchrony and response to cardiac resynchronization therapy.
Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Acute Effects of Fusion Pacing Versus Standard CRT on Myocardial Function in Heart Failure Patients with LBBB.Journal of clinical medicine · 2025Article
- Device-therapy in chronic heart failure: Cardiac contractility modulation versus cardiac resynchronization therapy.ESC heart failure · 2025Observational
- Impact of Intraventricular Blocks on Cardiac Cycle Dynamics: An Echocardiographic and Vectorcardiographic Analysis.Arquivos brasileiros de cardiologia · 2024Article
- Ventricular dysfunction consequences of mechanical dyssynchrony in isolated complete right bundle branch block versus left bundle branch block.Quantitative imaging in medicine and surgery · 2024Article
- Potential Underestimation of Left Ventricular Mechanical Dyssynchrony in Dyssynchrony and Outcomes Assessment.Journal of multidisciplinary healthcare · 2024Article
- Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Heart failure: an update from the last years and a look at the near future.ESC heart failure · 2022Review
- Shortening of time-to-peak left ventricular pressure rise (Td) in cardiac resynchronization therapy.ESC heart failure · 2021Observational
- Acute correction of electromechanical dyssynchrony and response to cardiac resynchronization therapy.ESC heart failure · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsEchocardiographic measures of dyssynchrony at baseline have not demonstrated a good ability to predict response to cardiac resynchronization therapy (CRT). The purpose of this study was to determine if the acute correction of electromechanical dyssynchrony, assessed by the change in simple pulsed-Doppler measures, was related to CRT response at 6 months. METHODS AND
resultsEchocardiography was performed at baseline and at pre-discharge after CRT implantation. Intraventricular, interventricular, and atrioventricular dyssynchrony were evaluated by the left pre-ejection interval (LPEI), the interventricular mechanical delay, and the ratio of left ventricular filling time to RR interval, respectivelxy. A patient was considered responder if he/she was alive without hospitalization for heart failure and had an absolute increase of left ventricular ejection fraction (LVEF) >5 points. Forty-eight patients (mean age 67 ± 11 years, 73% male, mean LVEF 30 ± 5%) were included. CRT led to an acute correction of intraventricular and interventricular dyssynchrony but not to an acute correction of atrioventricular dyssynchrony. There were 31 (65%) responders at 6 months. Two factors were independently associated with CRT response in multivariate analysis: ischemic cardiomyopathy (odds ratio 0.19, 95% confidence interval 0.04-0.87; P= 0.032) and delta LPEI (odds ratio 1.03 per 1 ms decrease, 95% confidence interval 1.01-1.05; P = 0.007). By receiver operating characteristic analysis, the optimal cut-off value of delta LPEI was -16 ms. The proportion of responders in patients without ischemic cardiomyopathy and with a delta LPEI greater than -16 ms was 85%.
conclusionsAcute correction of intraventricular electromechanical dyssynchrony evaluated by the LPEI predicted CRT response at 6 months.
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