ArticleJournal of clinical laboratory analysis2020
CircRNA hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Circular RNAs in gynecological cancer: From molecular mechanisms to clinical applications (Review).Oncology letters · 2025Review
- Mechanisms of apoptosis-related non-coding RNAs in ovarian cancer: a narrative review.Apoptosis : an international journal on programmed cell death · 2025Review
- Circular RNAs as a novel class of potential therapeutic and diagnostic biomarkers in reproductive biology/diseases.European journal of medical research · 2024Review
- Interplay of microRNAs and circRNAs in Epithelial Ovarian Cancer.Non-coding RNA · 2024Review
- Article
- Dysregulated Expression Patterns of Circular RNAs in Cancer: Uncovering Molecular Mechanisms and Biomarker Potential.Biomolecules · 2024Review
- The emerging roles and potential applications of circular RNAs in ovarian cancer: a comprehensive review.Journal of cancer research and clinical oncology · 2023Review
- MicroRNAs, long non-coding RNAs, and circular RNAs and gynecological cancers: focus on metastasis.Frontiers in oncology · 2023Review
- Review
- Emerging role of circular RNAs in the pathogenesis of ovarian cancer.Cancer cell international · 2022Review
- Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis.Bioengineered · 2022Article
- Roles and mechanisms of CircRNAs in ovarian cancer.Frontiers in cell and developmental biology · 2022Review
- Article
- CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review.Cellular & molecular biology letters · 2021Article
- Emerging important roles of circRNAs in human cancer and other diseases.Genes & diseases · 2021Review
- Circular RNA Circ_0013958 Functions as a Tumor Promoter in Ovarian Cancer by Regulating miR-637/PLXNB2 Axis.Frontiers in genetics · 2021Article
- Circ_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis.OncoTargets and therapy · 2021Article
- Circular RNAs: Novel biomarkers for cervical, ovarian and endometrial cancer (Review).Oncology reports · 2020Review
- CircRNA hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundCircRNA plays an important role in the development of tumors, but its mechanism of action in ovarian cancer is still unclear.
methodsThe expression level of hsa_circ_0013958 in 45 pairs of ovarian cancer tissues and cells was quantified by qRT-PCR, further revealing whether it is related to clinicopathological features and diagnostic value. Next, the effects of hsa_circ_0013958 on the proliferation, migration, invasion, and apoptosis of A2780 and OVCAR-3 cells were detected by CCK-8 assay, Transwell assay, and flow cytometry, respectively. Last, the expression levels of epithelial-mesenchymal transition-related proteins (E-cadherin and Vimentin) and apoptosis-related proteins (Bcl-2 and Bax) were detected by Western blotting.
resultsHsa_circ_0013958 was highly expressed in ovarian cancer tissues and cells, and its expression was closely related to patient FIGO stage and lymph node metastasis. Further, in vitro studies showed that knockdown of hsa_circ_0013958 suppressed proliferation, migration, and invasion of ovarian cancer cells but elevated the cell apoptotic rate. The expression levels of both epithelial-mesenchymal transition-related proteins and apoptosis-related proteins were also changed.
conclusionsHsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways.
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