Evidence map›Paper›PMID 32157726›Full record

ArticleThe EMBO journal2020

Alterations of redox and iron metabolism accompany the development of HIV latency.

Iart Luca Shytaj, Bojana Lucic, Mattia Forcato, Carlotta Penzo, James Billingsley, Vibor Laketa, Steven Bosinger, Mia Stanic, Francesco Gregoretti, Laura Antonelli and 9 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Logan: Planetary-Scale Genome Assembly Surveys Life's Diversity.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
  7. Fast pH-Driven Solubilization Method of Realgar (AsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Immuno-cell metabolic changes in HIV-1 infection.Infectious diseases & immunity · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 3 countries.

Iart Luca Shytaj *Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-9980-1275
Bojana Lucic *Heidelberg University Hospital, Heidelberg, Germany.
Mattia ForcatoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Carlotta PenzoHeidelberg University Hospital, Heidelberg, Germany.
James BillingsleyDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Vibor LaketaHeidelberg University Hospital, Heidelberg, Germany.
Steven BosingerDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Mia StanicHeidelberg University Hospital, Heidelberg, Germany.
Francesco GregorettiInstitute for High Performance Computing and Networking, ICAR-CNR, Naples, Italy.ORCID 0000-0003-3822-1215
Laura AntonelliInstitute for High Performance Computing and Networking, ICAR-CNR, Naples, Italy.
Gennaro OlivaInstitute for High Performance Computing and Networking, ICAR-CNR, Naples, Italy.
Christian K FreseCECAD Research Center, University of Cologne, Cologne, Germany.
Aleksandra TrifunovicCECAD Research Center, University of Cologne, Cologne, Germany.ORCID 0000-0002-5472-3517
Bruno GalyDivision of Virus-Associated Carcinogenesis, German Cancer Research Centre, Heidelberg, Germany.
Clarissa EiblLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany.
Guido SilvestriDivision of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Silvio BicciatoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.ORCID 0000-0002-1944-7078
Andrea SavarinoItalian Institute of Health, Rome, Italy.
Marina LusicHeidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0002-0120-3569
Heidelberg University · DEEmory University · USInstitute for High Performance Computing and Networking · ITUniversity of Cologne · DEUniversity of Modena and Reggio Emilia · ITGerman Cancer Research Center · DEHealth City Institute · ITHumboldt-Universität zu Berlin · DE

Funding

Deutsches Zentrum für Infektionsforschung (DZIF) 04.704Deutsches Zentrum für Infektionsforschung (DZIF) 04.810Gilead Sciences (Gilead)Humboldt Foundation
6 · The paper itself

Abstract

HIV-1 persists in a latent form during antiretroviral therapy, mainly in CD4

Indexed as

Gene Regulatory NetworksAnimalsCell LineDisease Models, AnimalHIV-1HIV InfectionsHumansIronMacacaOxidation-ReductionPromyelocytic Leukemia ProteinProteolysisSequence Analysis, RNASumoylationUp-RegulationVirus LatencyIronPML protein, humanPromyelocytic Leukemia ProteinHIV-1 latencyironoxidative stresspromyelocytic leukemia proteinproteasome

Identifiers

PMID32157726
PMCPMC7196916
OpenAlexW3011976283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.