Evidence map›Paper›PMID 32157661›Full record

ReviewCurrent nutrition reports2020

Metabolites Linking the Gut Microbiome with Risk for Type 2 Diabetes.

Tiantian Zhu, Mark O Goodarzi

Open access · greenAbstract readReview
In one paragraph

Review in Current nutrition reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Probiotic Supplementation and its Potential Benefits in Type 2 Diabetes: A Meta-analysis.Endocrine, metabolic & immune disorders drug targets · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. The Role of the Gut Microbiome in Type 2 Diabetes Mellitus.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Fecal Microbiome and Urine Metabolome Profiling of Type 2 Diabetes.Journal of microbiology and biotechnology · 2025
    Article
  13. Article
  14. Article
  15. Review
  16. Review
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Tiantian ZhuDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Room B-131, Los Angeles, CA, 90048, USA.
Mark O GoodarziDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Room B-131, Los Angeles, CA, 90048, USA. mark.goodarzi@cshs.org.
Cedars-Sinai Medical Center · US

Funding

Impact of the gut microbiome and diet on change in insulin homeostasis and cardiometabolic riskR01DK109588 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI GOODARZI, MARK, PETROSINO, JOSEPH FRANK · 2017 to 2021
$3.1M
NIDDK NIH HHS R01 DK109588
6 · The paper itself

Abstract

purpose of reviewAn increasing body of evidence suggests that the gut microbiome influences the pathogenesis of insulin resistance and type 2 diabetes (T2D). In this review, we will discuss the latest findings regarding the mechanisms linking the gut microbiome and microbial metabolites with T2D and therapeutic approaches based on the gut microbiota for the prevention and treatment of T2D. RECENT

findingsAlterations in the gut microbial composition are associated with the risk of T2D. The gut microbiota can metabolize dietary- and host-derived factors to produce numerous microbial metabolites, which are involved in metabolic processes modulating nutrition and energy harvest, gut barrier function, systemic inflammation, and glucose metabolism. Microbial metabolites are important mediators of microbial-host crosstalk impacting host glucose metabolism. Furthermore, microbiome-based interventions may have beneficial effects on glycemic control. Future research is required to develop personalized T2D therapy based on microbial composition and/or metabolites.

Indexed as

Gastrointestinal MicrobiomeHost Microbial InteractionsAmino Acids, Branched-ChainAnimalsBile Acids and SaltsDiabetes Mellitus, Type 2Diet TherapyFatty Acids, VolatileFecal Microbiota TransplantationHumansImidazolesIndolesInsulin ResistanceMethylaminesMiceProbiotics5-imidazolepropionic acidAmino Acids, Branched-ChainBile Acids and SaltsFatty Acids, VolatileImidazolesIndolesMethylaminestrimethyloxamineBranched-chain amino acidsGut microbiomeInsulin resistanceMicrobial metabolitesShort-chain fatty acidsT2D

Identifiers

PMID32157661
PMCPMC7282969
OpenAlexW3012071280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.