Evidence map›Paper›PMID 32157637›Full record

ArticlePathology oncology research : POR2020

Methylation Statuses of H19DMR and KvDMR at WT2 in Wilms Tumors in Taiwan.

Meng-Yao Lu, Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Yen-Chein Lai

Erratum issuedAbstract read
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In one paragraph

Article in Pathology oncology research : POR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Meng-Yao LuDepartment of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan.
Wen-Chung WangDepartment of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung, Taiwan.
Tai-Cheng HouDepartment of Pathology, Jen-Ai Hospital, Taichung, Taiwan.
Chen-Yun KuoDepartment of Pathology, Jen-Ai Hospital, Taichung, Taiwan.
Yen-Chein LaiDepartment of Medical Laboratory and Biotechnology, Chung Shan Medical University, No.110, Sec. 1, Chien Kuo N. Road, Taichung, 402, Taiwan. yenchein@csmu.edu.tw.
Jen-Ai Hospital · TWChung Shan Medical University Hospital · TWNational Taiwan University Hospital · TW

Funding

Chung Shan Medical University CSMU-INT-108-2
6 · The paper itself

Abstract

Wilms tumor is the most common pediatric renal malignancy. Several genetic loci have been shown to be associated with its formation. Genetic or epigenetic aberrations at WT1 and WT2 loci have been implicated in the etiology of the majority of sporadic Wilms tumors. In our previous study, most Wilms tumors tested negative for both constitutional mutations and somatic mutations in the WT1 gene. Thus, WT2 may play an important role in these tumors. In the present study, we analyzed the methylation statuses of WT2 at 11p15 using methylation sensitive multiplex ligation-dependent probe amplification in six Wilms tumors. Paternal uniparental disomy at WT2 was observed in two Wilms tumors with epithelial components due to hypermethylation at H19DMR and hypomethylation at KvDMR. Our findings highlight the benefits of testing for 11p15 epigenetic abnormalities to identify Wilms tumors with epithelial components.

Indexed as

Chromosome AberrationsDNA MethylationGenes, Wilms TumorGenomic ImprintingBiomarkers, TumorCpG IslandsEpigenomicsFemaleHumansKidney NeoplasmsMaleMutationPrognosisRNA, Long NoncodingWilms TumorBiomarkers, TumorH19 long non-coding RNARNA, Long NoncodingMultiplex ligation-dependent probe amplificationNephroblastomaPaternal uniparental disomyWilms tumor

Identifiers

PMID32157637
OpenAlexW3011130319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.