ArticleBrain imaging and behavior2020
Atrophy of right inferior frontal orbital gyrus and frontoparietal functional connectivity abnormality in depressed suicide attempters.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Functional Breakdown of Temporoparietal Junction Interaction in High-depression Individuals: Evidence from Multi-Metric Connectomics.Brain structure & function · 2026Article
- Article
- Relationship between serum inflammatory cytokines and suicide risk in patients with major depressive disorder.Frontiers in psychiatry · 2024Article
- Connectomics-based resting-state functional network alterations predict suicidality in major depressive disorder.Translational psychiatry · 2023Article
- Machine learning based identification of structural brain alterations underlying suicide risk in adolescents.Discover mental health · 2023Article
- Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies.Frontiers in psychiatry · 2023Review
- Investigation of changes in the activity and function of dry eye-associated brain regions using the amplitude of low-frequency fluctuations method.Bioscience reports · 2022Article
- Shared and distinct functional connectivity of hippocampal subregions in schizophrenia, bipolar disorder, and major depressive disorder.Frontiers in psychiatry · 2022Article
- White Matter Network Disruption Is Associated With Melancholic Features in Major Depressive Disorder.Frontiers in psychiatry · 2022Article
- Identifying Changes of Brain Regional Homogeneity and Cingulo-Opercular Network Connectivity in First-Episode, Drug-Naïve Depressive Patients With Suicidal Ideation.Frontiers in neuroscience · 2022Article
- New Methods for Assessing Rapid Changes in Suicide Risk.Frontiers in psychiatry · 2021Review
- Amplitude of Low-Frequency Fluctuation in Multiple Frequency Bands in Tension-Type Headache Patients: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in neuroscience · 2021Article
- Association between suicide risk severity and sarcopenia in non-elderly Chinese inpatients with major depressive disorder.BMC psychiatry · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
Although structural and functional brain abnormalities have been observed in depressed suicide attempters (DS), structural deficits and functional impairments together with their relationship in DS remain unclear. To clarify this issue, we aimed to examine the differences in gray matter (GM) alteration, corresponding functional connectivity (FC) change, and their relationship between DS and depressed non-suicide attempters (NDS). Sixty-eight DS, 119 NDS and 103 healthy controls were enrolled and subjected to magnetic resonance imaging scans. The patients were evaluated using the 17-item Hamilton Rating Scale for Depression (HRSD) and Nurses' Global Assessment of Suicide Risk (NGASR) scale. Both voxel-based morphometry and resting-state FC analyses were performed based on functional and structural imaging data. Compared with NDS, the DS group showed reduced GM volume in the right inferior frontal orbital gyrus (IFOG) and left caudate (CAU) but increased GM volume in the left calcarine fissure, weaker negative right IFOG-left rectus gyrus (REG) FC, and weaker positive right IFOG-left inferior parietal lobule (IPL) FC. In DS, the GM volume of the right IFOG and left CAU was negatively correlated with NGASR and HRSD scores, respectively; the right IFOG-left IPL FC was negatively correlated with cognitive factor scores; and the GM volume of the right IFOG was positively correlated with IFOG-REG and IFOG-IPL FC. Our findings indicate that structural deficit with its related functional alterations in brain circuits converged in right IFOG centralized pathways and may play a central role in suicidal behaviors in depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.