Evidence map›Paper›PMID 32157432›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Multiparametric imaging hippocampal neurodegeneration and functional connectivity with simultaneous PET/MRI in Alzheimer's disease.

Shaozhen Yan, Chaojie Zheng, Bixiao Cui, Zhigang Qi, Zhilian Zhao, Yanhong An, Liyan Qiao, Ying Han, Yun Zhou, Jie Lu

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  13. The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Shaozhen YanDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chaojie ZhengMallinckrodt Institute of Radiology, Washington University School of Medicine, 510 Kingshighway Blvd., St. Louis, MO, USA.
Bixiao CuiDepartment of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhigang QiDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhilian ZhaoDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yanhong AnDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Liyan QiaoDepartment of Neurology, Yuquan Hospital, Clinical Neuroscience Institute, Medical Center, Tsinghua University, Beijing, China.
Ying HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yun ZhouMallinckrodt Institute of Radiology, Washington University School of Medicine, 510 Kingshighway Blvd., St. Louis, MO, USA. yunzhou@wustl.edu.
Jie LuDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China. imaginglu@hotmail.com.ORCID 0000-0003-0425-3921
Capital Medical University · CNMallinckrodt (United States) · USTsinghua University · CN

Funding

Beijing Municipal Administration of Hospitals' Ascent Plan DFL20180802Beijing Municipal Commission of Science and Technology Z171100000117001Key laboratory of Neurodegenerative diseases, Ministry of Education PXM2019_026283_000003National Key Research and Development Program of China 2016YFC0103909National Natural Science Foundation of China 81141018National Natural Science Foundation of China 81801677
6 · The paper itself

Abstract

purposeThe objective of this study is to investigate the hippocampal neurodegeneration and its associated aberrant functions in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients using simultaneous PET/MRI.

methodsForty-two cognitively normal controls (NC), 38 MCI, and 22 AD patients were enrolled in this study. All subjects underwent

resultsPatient groups had reduced SUVR, gray matter volume, and functional connectivity compared to NC in CA1, CA2/3/DG, and subiculum (AD < MCI < NC). There was a linear correlation between the left CA2/3DG gray matter volume and

conclusionOur findings demonstrate that the associations existed at subregional hippocampal level between the functional connectivity measured by fMRI and neurodegeneration measured by structural MRI and

Indexed as

Alzheimer DiseaseCognitive DysfunctionFluorodeoxyglucose F18HippocampusHumansMagnetic Resonance ImagingPositron-Emission TomographyFluorodeoxyglucose F18Alzheimer’s diseaseHippocampal subregionsHybrid PET/MRINeurodegenerationVoxel-based morphometric analysis

Identifiers

PMID32157432
PMCPMC7396401
OpenAlexW3011237672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.