ArticleEuropean journal of nuclear medicine and molecular imaging2020
Extracardiac soft tissue uptake, evidenced on early
Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Diagnostic performance of CMR, SPECT, and PET imaging for the detection of cardiac amyloidosis: a meta-analysis.BMC cardiovascular disorders · 2021Pooled it
- Visceral technetium-99 m-labeled pyrophosphate uptake in patients with wild-type transthyretin cardiac amyloidosis.Annals of nuclear medicine · 2026Article
- Association Between Severe Aortic Stenosis and Amyloid Deposition in the Myocardium of Patients With Wild-Type Transthyretin Cardiac Amyloidosis.Circulation reports · 2026Article
- Article
- Impact of disease-modifying therapy on [European journal of nuclear medicine and molecular imaging · 2026Article
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- Technetium-99m-labeled pyrophosphate uptake in the rectum of a patient with wild-type transthyretin cardiac amyloidosis.Radiology case reports · 2026Article
- Diagnostic Accuracy of Bisphosphonate Scintigraphy in Glu54GlnATTR Cardiomyopathy.Journal of clinical medicine · 2025Article
- Hereditary transthyretin amyloidosis incidentally diagnosed by video-associated lung surgery for lung cancer: A case report.Respiratory medicine case reports · 2025Article
- [European journal of nuclear medicine and molecular imaging · 2024Article
- Article
- Cardiac Amyloidosis, Should We See It from the Side or the Front?Annals of nuclear cardiology · 2024Article
- Extra-cardiac uptake on technetium-99m pyrophosphate (Tc-99m PYP) scan: not just a matter of the heart.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Radiopharmaceutical supply disruptions and the use ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Heart Transplantation, Either Alone or Combined With Liver and Kidney, a Viable Treatment Option for Selected Patients With Severe Cardiac Amyloidosis.Transplantation direct · 2022Article
- Diagnosis of cardiac amyloid transthyretin (ATTR) amyloidosis by early (soft tissue) phase [European radiology · 2022Article
- Variability in bone-seeking tracers and imaging protocols for the diagnosis of cardiac amyloidosis: The more the merrier?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- History of extracardiac/cardiac events in cardiac amyloidosis: prevalence and time from initial onset to diagnosis.ESC heart failure · 2021Article
- Nuclear Imaging for Cardiac Amyloidosis: Bone Scan, SPECT/CT, and Amyloid-Targeting PET.Nuclear medicine and molecular imaging · 2021Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncreased cardiac uptake (CU) on early-phase
methodsWe reviewed all patients referred for suspicion of CA, who underwent
resultsOf 308 eligible patients, 247 had CA, including 75 ATTRv, 107 ATTRwt, and 65 light-chain (AL), while 61 had another cardiopathy (controls). ECU was observed in 29% of CA and 3% of controls. Most frequent sites of ECU were pleuropulmonary (16% of CA, 3% of controls) followed by the digestive tract and subcutaneous tissues. The liver and spleen ECU was only observed in AL-CA (n = 8). CU was only observed in CA patients (n = 187), of whom 182 had ATTR-CA vs. 5 AL-CA, P < 0.001. MADI0 was only observed in controls (97%) and in AL-CA (60%). MADI1 was mainly observed in AL-CA (positive predictive value, PPV = 91%) while MADI2/3 were more frequent in ATTR-CA (PPV = 97%), P < 0.0001. MADI > 0 vs. MADI0 in AL and MADI3 vs. MADI2 in ATTR were associated with a worse prognosis (P = 0.03 and P = 0.002, respectively).
conclusionsECU combined with CU demonstrates high diagnostic and prognostic values in CA patients. MADI seems an easy and reliable score in clinical practice.
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